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Doctor Reviews: Puravive

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When checking out a weight loss supplement like Puravive, it’s essential to be cautious about their weight-loss promises. They often talk about revealing new secrets for losing weight, but let’s take a closer look at Puravive’s claims. They suggest that low levels of brown adipose tissue contribute to obesity, citing two articles to support their stance. However, we need to dig deeper into those articles to understand the actual story. Do these studies genuinely show that low brown adipose tissue levels lead to obesity?

Puravive’s misleading claims

Let’s dive into Puravive’s weight loss assertions and separate fact from fiction.

Claim 1: BAT and Obesity

Puravive suggests that having high levels of brown adipose tissue makes people skinny. However, the supporting article they reference actually connects BAT to overall heart health, not weight loss. The study indicates a link between increased BAT and a lower risk of diabetes and heart disease, particularly in obese individuals. Contrary to Puravive’s claim, the study doesn’t say that skinny people have more BAT or that BAT aids weight loss. It merely suggests that BAT may reduce cardiovascular risks in obese individuals.

Claim 2: Burning Capacity of BAT

Puravive states that BAT can burn 300 times more calories than any other cell. However, the cited study focuses on seasonal changes in BAT activity, not its calorie-burning capacity. Puravive might have cherry-picked a statement about BAT producing more heat, not necessarily burning calories. Moreover, the study concentrates on BAT in fetuses, not adults.

Claim 3: Ingredients Activating BAT

Puravive references articles claiming their ingredients activate BAT. It’s crucial to prioritize studies demonstrating actual weight loss or BAT activation in humans, not just in cells or mice. None of Puravive’s references are human studies; they’re all conducted on cells or mice. While these studies offer insights, human metabolism is complex, and findings in cells or mice don’t guarantee weight loss in humans. Without human studies demonstrating weight loss benefits, we can’t confidently say Puravive effectively addresses obesity.

BAT and Weight Loss

So, the big question on your mind might be: Can activating brown adipose tissue (BAT) actually help with weight loss? Theoretically, it’s a possibility, but let’s break it down realistically. BAT in adults primarily works to keep us warm by generating heat when we’re cold. It’s not like regular fat that contributes significantly to our body weight; instead, adults only have small amounts of BAT, around 0.1% of body weight, compared to the 20-25% that regular fat makes up.

Despite its role in thermoregulation, studies attempting to boost BAT activation through cold exposure in humans haven’t shown any substantial weight loss effects. Even if you could somehow activate all your BAT, the calorie burn might not translate into significant weight loss, though it could offer cardiovascular benefits.

Moreover, BAT becomes active mainly in a cold environment to generate heat. It doesn’t just kick in randomly, meaning you’d need to consistently expose yourself to cold conditions for BAT to burn calories. If the idea of shivering in a chilly room for hours to burn a small number of calories doesn’t sound practical, then relying on BAT activation for weight loss may not be the most effective strategy.

Puravive’s Ingredients

Now, let’s get into the nitty-gritty of Puravive’s ingredients. The recommended daily dose is just one capsule.

Puravive-review-ingredients
Ingredients of Puravive supplement.

But here’s where it gets interesting—the ingredients are essentially a rebranded version of another supplement called Exipure. Beyond the similar ingredients, both websites use identical templates and language to promote these supplements. They even share nearly identical bottle designs.

Upon closer examination, the ingredients match up, with a slight difference in labeling. Puravive uses “luteolin,” while Exipure goes for “Perilla extract.” But here’s the kicker—luteolin is a component found in Perilla extracts, and it’s clearly mentioned on both bottles.

Leaf and Olive Extract

Olive oil is packed with heart-healthy polyunsaturated fats, which can be good for your heart and metabolism. However, going for olive oil supplements may not be the best move. You can easily get the same benefits by drizzling regular extra virgin olive oil on your salad. Plus, it’s more cost-effective. Most studies showing olive oil’s perks involve incorporating it into your diet, not through supplements. The likely reason is that the amounts used in these studies go way beyond what Puravive provides.

Holy Basil

Holy Basil, an Ayurvedic herb, is often used to tackle inflammation. While there’s not much evidence supporting its weight loss claims, it shows slight promise in helping diabetics control blood sugar levels. But here’s the catch – the doses in studies are way higher (around 500 mg daily) than what Puravive offers.

Bee Propolis

Bee Propolis, a concoction made by honey bees, is known for its sealant-like properties in beehives. While studies hint at its potential for aiding diabetics, the snag is in the dosage. Most studies use nearly 1000 mg per day, much more than what you’ll find in Puravive. So, don’t expect any practical benefits from the dosage in this supplement.

Amur Cork Tree and Kudzu

These traditional herbs have historical use for inflammation and gastrointestinal issues. While amur cork tree contains berberine, a compound with potential insulin sensitivity benefits, the doses needed (1-2 grams daily) are far beyond what Puravive provides.

Quercetin

Quercetin, found in fruits and berries, is great for overall health, but it doesn’t contribute to weight loss. The hitch with Puravive is that the amounts used in beneficial studies are way more than what one pill of this supplement can offer.

Korean Ginseng

Known for its stimulating effects, Korean ginseng might help combat fatigue and enhance concentration. It’s also linked to blood sugar control in diabetes. However, effective doses in studies range from 200 to almost 1000 mg per day, raising questions about the effectiveness of the small amounts in Puravive.

Luteolin

Present in green veggies, egg yolk, squash, and corn, luteolin doesn’t show any weight loss benefits. Puravive uses perilla extracts as a source of luteolin.

Side Effects and Concerns

Let’s talk about some safety aspects and considerations regarding Puravive. One thing to keep in mind is the presence of berberine in its ingredients. While the exact amount isn’t specified, berberine has the potential to interact with other medications. If you’re currently on any medication, it’s crucial to have a chat with your doctor before thinking about incorporating this supplement into your routine. Another key point is that berberine is a no-go during pregnancy or breastfeeding.

Is Puravive effective?

Now, the big question: Does Puravive actually work? Well, after digging into all the details, it seems like this supplement is completely useless for weight loss. In fact, it appears to lack any practical health benefits.

Puravive-review-ingredient-analysis
Puravive supplement review ingredient analysis.

It seems to lean weakly towards helping control blood sugar, specifically for those dealing with metabolic issues like diabetes. But if you’re in the clear when it comes to diabetes or blood sugar concerns, it’s likely that Puravive won’t show any noticeable effects. Even for those with blood sugar issues, the low dosages across all components might render it ineffective.

Considering the overall lack of effectiveness in Puravive, it’s a bit tricky to compare it to other options. However, if I had to throw in a recommendation, focusing on berberine might be a more fruitful endeavor. Berberine has the potential to assist with blood sugar control in diabetics, indirectly contributing to weight management.

Overall review: Puravive

Puravive-review-overall-summary-rating
Overall rating NiteLEAN review summary.

Reviewing Puravive by effectiveness for weight loss, I’m giving it an F. I don’t expect it to do much of anything. Even if you have diabetes, the doses it uses are likely so low it probably still wont do anything.

Reviewing Puravive by cost, I’m giving it an F. It’s pretty expensive for such a useless supplement.

Reviewing Puravive for safety, I’m giving it a B. Although the ingredients seem mostly safe to take, the lack of information about this particular supplement makes it really sketchy to take.

Overall review, I’m giving Puravive an F. I would recommend you stay away from it.

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Citations

Abdelazim A, Khater S, Ali H, et al. Panax ginseng improves glucose metabolism in streptozotocin-induced diabetic rats through 5′ adenosine monophosphate kinase up-regulation. Saudi J Biol Sci. 2019;26(7):1436-1441. doi:10.1016/j.sjbs.2018.06.001

Afsharpour F, Javadi M, Hashemipour S, Koushan Y, Haghighian HK. Propolis supplementation improves glycemic and antioxidant status in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled study. Complement Ther Med. 2019;43:283-288. doi:10.1016/j.ctim.2019.03.001

Agrawal P, Rai V, Singh RB. Randomized placebo-controlled, single blind trial of holy basil leaves in patients with noninsulin-dependent diabetes mellitus. Int J Clin Pharmacol Ther 1996;34:406-9.

An Y, Sun Z, Zhang Y, Liu B, Guan Y, Lu M. The use of berberine for women with polycystic ovary syndrome undergoing IVF treatment. Clin Endocrinol (Oxf) 2014;80(3):425-31.

Arentz S, Smith CA, Abbott J, Bensoussan A. Nutritional supplements and herbal medicines for women with polycystic ovary syndrome; a systematic review and meta-analysis. BMC Complement Altern Med. 2017;17(1):500.

Bes-Rastrollo M, Sánchez-Villegas A, de la Fuente C, de Irala J, Martinez JA, Martínez-González MA. Olive oil consumption and weight change: the SUN prospective cohort study. Lipids. 2006;41(3):249-256. doi:10.1007/s11745-006-5094-6

El-Sharkawy HM, Anees MM, Van Dyke TE. Propolis improves periodontal status and glycemic control in patients with type 2 diabetes mellitus and chronic periodontitis: A randomized clinical trial. J Periodontol. 2016;87(12):1418-1426.

Geng J, Dong J, Ni H, et al. Ginseng for cognition. Cochrane Database Syst Rev. 2010;(12):CD007769. Published 2010 Dec 8. doi:10.1002/14651858.CD007769.pub2

Guasch-Ferré M, Hu FB, Martínez-González MA, et al. Olive oil intake and risk of cardiovascular disease and mortality in the PREDIMED Study. BMC Med. 2014;12:78. Published 2014 May 13. doi:10.1186/1741-7015-12-78

Guasch-Ferré M, Liu G, Li Y, et al. Olive Oil Consumption and Cardiovascular Risk in U.S. Adults. J Am Coll Cardiol. 2020;75(15):1729-1739. doi:10.1016/j.jacc.2020.02.036

Guo J, Chen H, Zhang X, et al. The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Oxid Med Cell Longev. 2021;2021:2074610. Published 2021 Dec 15. doi:10.1155/2021/2074610

Huang XS, Yang GF, Pan YC. Effect of berberin hydrochloride on blood concentration of cyclosporine A in cardiac transplanted patients. Zhongguo Zhong Xi Yi Jie He Za Zhi 2008;28:702-4.

Jakaria M, Haque ME, Kim J, Cho DY, Kim IS, Choi DK. Active ginseng components in cognitive impairment: Therapeutic potential and prospects for delivery and clinical study. Oncotarget. 2018 Sep 11;9(71):33601-33620. doi: 10.18632/oncotarget.26035. PMID: 30323902; PMCID: PMC6173364.

Karimian J, Hadi A, Pourmasoumi M, Najafgholizadeh A, Ghavami A. The efficacy of propolis on markers of glycemic control in adults with type 2 diabetes mellitus: a systematic review and meta-analysis. Phytother Res 2019;33(6):1616-26.

Katsiki N, Pérez-Martínez P, Lopez-Miranda J. Olive Oil Intake and Cardiovascular Disease Prevention: "Seek and You Shall Find". Curr Cardiol Rep. 2021;23(6):64. Published 2021 May 7. doi:10.1007/s11886-021-01496-1

Knab AM, Shanely RA, Jin F, Austin MD, Sha W, Nieman DC. Quercetin with vitamin C and niacin does not affect body mass or composition. Appl Physiol Nutr Metab. 2011;36(3):331-8.

Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015;161:69-81.

Lee ST, Chu K, Sim JY, Heo JH, Kim M. Panax ginseng enhances cognitive performance in Alzheimer disease. Alzheimer Dis Assoc Disord. 2008;22(3):222-226. doi:10.1097/WAD.0b013e31816c92e6

Marlatt KL, Ravussin E. Brown Adipose Tissue: an Update on Recent Findings. Curr Obes Rep. 2017 Dec;6(4):389-396. doi: 10.1007/s13679-017-0283-6. PMID: 29101739; PMCID: PMC5777285.

Martínez-González MA, Sayón-Orea C, Bullón-Vela V, et al. Effect of olive oil consumption on cardiovascular disease, cancer, type 2 diabetes, and all-cause mortality: A systematic review and meta-analysis. Clin Nutr. 2022;41(12):2659-2682. doi:10.1016/j.clnu.2022.10.001

Oh MR, Park SH, Kim SY, et al. Postprandial glucose-lowering effects of fermented red ginseng in subjects with impaired fasting glucose or type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial. BMC Complement Altern Med. 2014;14:237. Published 2014 Jul 11. doi:10.1186/1472-6882-14-237

Park KC, Jin H, Zheng R, et al. Cognition enhancing effect of panax ginseng in Korean volunteers with mild cognitive impairment: a randomized, double-blind, placebo-controlled clinical trial. Transl Clin Pharmacol. 2019;27(3):92-97. doi:10.12793/tcp.2019.27.3.92

Pérez-Martínez P, García-Ríos A, Delgado-Lista J, Pérez-Jiménez F, López-Miranda J. Mediterranean diet rich in olive oil and obesity, metabolic syndrome and diabetes mellitus. Curr Pharm Des. 2011;17(8):769-777. doi:10.2174/138161211795428948

Reay JL, Kennedy DO, Scholey AB. Effects of Panax ginseng, consumed with and without glucose, on blood glucose levels and cognitive performance during sustained ‘mentally demanding’ tasks. J Psychopharmacol. 2006;20(6):771-781. doi:10.1177/0269881106061516

Reay JL, Kennedy DO, Scholey AB. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. J Psychopharmacol. 2005;19(4):357-365. doi:10.1177/0269881105053286

Samadi N, Mozaffari-Khosravi H, Rahmanian M, Askarishahi M. Effects of bee propolis supplementation on glycemic control, lipid profile and insulin resistance indices in patients with type 2 diabetes: a randomized, double-blind clinical trial. J Integr Med. 2017;15(2):124-134.

Shishtar E, Sievenpiper JL, Djedovic V, et al. The effect of ginseng (the genus panax) on glycemic control: a systematic review and meta-analysis of randomized controlled clinical trials. PLoS One. 2014;9(9):e107391. Published 2014 Sep 29. doi:10.1371/journal.pone.0107391

Somasundaram G, Manimekalai K, Salwe KJ, Pandiamunian J. Evaluation of the antidiabetic effect of Ocimum sanctum in type 2 diabetes patients. Int J Life Sci Pharma Res 2012;2(3):75-81.

Sun W, Frost B, Liu J. Oleuropein, unexpected benefits! Oncotarget. 2017 Mar 14;8(11):17409. doi: 10.18632/oncotarget.15538. PMID: 28407695; PMCID: PMC5392257.

Uemura T, Yashiro T, Oda R, et al. Intestinal anti-inflammatory activity of perillaldehyde. J Agric Food Chem. 2018;66(13):3443-3448.

Vuksan V, Sung MK, Sievenpiper JL, et al. Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: results of a randomized, double-blind, placebo-controlled study of efficacy and safety. Nutr Metab Cardiovasc Dis. 2008;18(1):46-56. doi:10.1016/j.numecd.2006.04.003

Wei, W., Zhao, H., Wang, A., Sui, M., Liang, K., Deng, H., Ma, Y., Zhang, Y., Zhang, H., and Guan, Y. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome. Eur J Endocrinol. 2012;166(1):99-105.

Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72.

Yu H, Qiu JF, Ma LJ, Hu YJ, Li P, Wan JB. Phytochemical and phytopharmacological review of Perilla frutescens L. (Labiatae), a traditional edible-medicinal herb in China. Food Chem Toxicol 2017;108(Pt B):375-91.

Yubero-Serrano EM, Lopez-Moreno J, Gomez-Delgado F, Lopez-Miranda J. Extra virgin olive oil: More than a healthy fat. Eur J Clin Nutr. 2019;72(Suppl 1):8-17. doi:10.1038/s41430-018-0304-x

Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93:2559-65.

Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z. Z., Wang, S. K., Zhou, Z. X., Song, D. Q., Wang, Y. M., Pan, H. N., Kong, W. J., and Jiang, J. D. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism 2010;59(2):285-292.

Zhao L, Pu L, Wei J, et al. Brazilian green propolis improves antioxidant function in patients with type 2 diabetes mellitus. Int J Environ Res Public Health 2016;13(5). pii: E498.


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