Vitamin C for Radiant Skin

Watch this on YouTube.

You’ve probably heard that Vitamin C is a game-changer for your skin. It’s touted for boosting collagen production, aiding skin regeneration, and protecting against sun damage thanks to its antioxidant properties. But let’s put aside the theories, marketing hype, influencer reviews, and overblown promises. Instead, we’ll dive into what human clinical research actually tells us. No biases or conflicts of interest—just the facts. So, what do clinical trials reveal about the real benefits of using Vitamin C for skin care?

Vitamin C vs Ascorbic acid

You may have heard the terms “Vitamin C” and “ascorbic acid” used interchangeably, but they aren’t exactly the same. Ascorbic acid is a single compound—the purest and simplest chemical form of Vitamin C. Vitamin C, however, refers to all chemicals and compounds exhibiting Vitamin C activity, meaning they act like Vitamin C in the body. Compounds like sodium ascorbate, calcium ascorbate, and other mineral ascorbates are all considered forms of Vitamin C, just like ascorbic acid. Although these compounds differ, the body metabolizes them all to use as Vitamin C.

Topical Forms of Vitamin C

So, if they all end up as Vitamin C in the body, do different types have different effects on the skin? Absolutely. Each form of Vitamin C has unique stability and chemical properties. For instance, ascorbic acid is the most widely studied form of Vitamin C for the skin and is commonly used in topical serums and cosmetics. However, it doesn’t penetrate the skin well and quickly breaks down when exposed to air.

To address these issues, manufacturers and researchers have developed various methods. One approach is reducing the acidity of ascorbic acid to improve its stability and skin penetration. Combining ascorbic acid with ferulic acid, another powerful antioxidant, helps stabilize Vitamin C and protect it from degradation.

Another strategy involves creating Vitamin C derivatives by combining it with stable molecules. Common derivatives include ascorbyl-6-palmitate and magnesium ascorbyl phosphate (MAP), both highly stable at low acidity. Other examples are disodium isostearyl ascorbyl phosphate, ascorbic acid sulfate, and tetra-isopalmitoyl ascorbic acid. Studies show these derivatives are much more stable than regular ascorbic acid.

However, stability alone doesn’t guarantee better Vitamin C delivery. Some studies show that daily application of these derivatives does not increase ascorbic acid levels in the skin. This could be because the derivatives are too stable and don’t break down efficiently to release Vitamin C into the skin. Finding the right balance between stability and bioavailability is crucial for determining the best form of Vitamin C for specific skin concerns.

Optimal Concentration of Vitamin C

When it comes to how much to use, the optimal concentration of Vitamin C depends on its formulation. Typically, a product needs a Vitamin C concentration higher than 8% to be biologically significant. Studies show that concentrations above 20% don’t increase benefits and may cause skin irritation. That’s why most reputable skincare products contain around 10-20% Vitamin C.

It’s important to note that most studies on Vitamin C for skincare use pure ascorbic acid, not combined with ferulic acid or in its derivative forms. This doesn’t mean these other formulations aren’t beneficial, but the overall weight of evidence suggests that using ascorbic acid is likely just as good in most cases for skin health as the newer, fancier formulations.

Skin Benefits of Vitamin C

Vitamin C and Wrinkles

Does Vitamin C help reduce wrinkles? We’re focusing on wrinkles due to aging, not those caused by excessive UV damage—we’ll cover those later.

Some evidence shows that applying Vitamin C to the skin for 12 weeks can reduce facial wrinkles. For instance, a small clinical study found that using a microneedle patch containing Vitamin C every four days for 12 weeks reduced the appearance of crow’s feet. Another study with women aged 30-60 showed that applying an oil-soluble cream with the Vitamin C derivative tetra-isopalmitoyl ascorbic acid (VC-IP) twice daily for eight weeks reduced wrinkles compared to a placebo.

So, topical Vitamin C may help reduce the appearance of wrinkles. However, these benefits come from specialized formulations that improve Vitamin C absorption into the skin, such as oil/water emulsions, oil-soluble derivatives like VC-IP, or microneedles to drive the ascorbic acid into the skin. Simply applying pure ascorbic acid to the skin likely doesn’t have the same effect. Additionally, these studies focused on topical applications, not oral consumption—there’s no evidence that taking Vitamin C supplements helps with wrinkles.

It’s important to note that reducing the appearance of wrinkles is not the same as having anti-aging effects. While Vitamin C may reduce the appearance of wrinkles, there is no evidence that it can reverse or slow down the natural aging process of the skin.

Vitamin C and Sun Protection

Does Vitamin C help reduce sun damage, also known as photoaging?

Applying topical Vitamin C along with Vitamin E and melatonin seems to provide modest photoprotective effects when used before UV exposure. However, topical Vitamin C has no benefits if used during or after UV exposure.

Oral Vitamin C may have benefits after UV exposure. Taking Vitamin C with Vitamin E appears to prevent UV-induced redness and protect against skin inflammation after UV exposure.

So, Vitamin C may slightly protect the skin from UV damage. However, in these clinical trials, ascorbic acid was always combined with another antioxidant like Vitamin E or melatonin. This makes it hard to determine if the beneficial effects are from ascorbic acid itself or the other antioxidants.

Both topical and oral forms of ascorbic acid were used. Topical ascorbic acid didn’t require any special oil emulsions and acted like a weak sunscreen. The key here is freshness, as ascorbic acid degrades quickly when exposed to the environment. Preparing your own ascorbic acid solution or cream might be a viable alternative to commercial Vitamin C formulations for sun protection. It may help block some sun damage if applied before exposure but likely has no effect if applied afterward. If you want to reduce sun damage after exposure, taking Vitamin C orally may be the way to go.

Vitamin C and Acne

Does Vitamin C help with acne or acne scarring?

One small clinical study showed that applying a Vitamin C serum to the face after microneedling treatment for four months improved the appearance of acne scars compared to the baseline. However, no statistical comparisons were conducted, so we don’t know how significant the benefit was. In another small study, a Vitamin C derivative called ascorbyl-2-phosphate was applied topically for 12 weeks and showed a small improvement in acne.

So, there is weak evidence suggesting that Vitamin C, specifically ascorbyl-2-phosphate, may slightly help with acne. Vitamin C may also help reduce acne scarring, but only when used with microneedling. Microneedling, also known as collagen induction therapy, involves using fine needles to create tiny, controlled punctures in the skin. These micro-injuries stimulate the body’s natural wound healing processes, leading to the production of new collagen and elastin. For acne scars, microneedling can improve texture and appearance by breaking down old scar tissue and promoting the formation of new, healthier skin. Applying Vitamin C during this treatment can help improve healing.

Vitamin C and Dark Spots

Does Vitamin C help with hyperpigmentation?

In a small study involving women with melasma, applying a 25% Vitamin C solution with a chemical penetration enhancer decreased pigmentation after 16 weeks. Another small study found that a Vitamin C derivative, magnesium ascorbyl phosphate, slightly reduced pigmentation.

However, none of these trials were placebo-controlled. So the research on Vitamin C for dark spots is weak and has primarily focused on hyperpigmentation due to melasma. Melasma is a common skin condition that causes dark, discolored patches, mainly on the face. It’s more prevalent in women, especially during pregnancy or when using oral contraceptives, and is often triggered by hormonal changes and aggravated by sun or UV exposure.

Summary

Overall, there is some evidence that Vitamin C and its derivatives can benefit various skin issues. It has decent evidence for reducing the appearance of wrinkles and protecting against UV damage. If you’re using it for wrinkles, make sure you choose a formulation that promotes Vitamin C absorption into the skin. For UV protection, combining it with Vitamin E and using it before sun exposure seems effective.

However, the evidence is much weaker for helping with acne, scarring, or reducing pigmentation. The benefits in these areas are likely small. You may not notice much improvement unless you use specialized tools to examine your skin closely or meticulously count your acne or wrinkles. Ascorbic acid is probably the most beneficial form of Vitamin C for these conditions, although derivatives like VC-IP, ascorbyl-2-phosphate, and MAP have shown potential benefits.

Top supplement choices

• Vitamin C (caps) – 1 cap / day
• Vitamin C (cream) – topically
• Vitamin C (powder) – 1 sachet / day

Learn more about

• Supplement reviews

See also

• 
  The Benefits of Ashwaghanda
  Ashwagandha is well-known for its benefits in reducing stress and anxiety, with most of the research coming from India and the Middle East.
• 
  The Benefits of Schisandra
  The clinical evidence supporting schisandra’s medicinal benefits is too weak. However, it shines as a nutritious functional food.
• 
  Vitamin C for Radiant Skin
  Vitamin C can help reduce wrinkles and protect against UV damage, but there isn’t much proof it works for dark spots or acne.
• 
  Akkermansia Muciniphila for Weight Loss
  Akkermansia Muciniphila may lower obesity risks and improve cardiovascular health, but evidence for weight loss is weak.
• 
  Niacinamide for Clear Skin
  Niacinamide effectively reduces acne and protects against sun damage, with weaker evidence for managing dark spots, wrinkles, and aging skin.