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Doctor Reviews: GOLO Release

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When you visit the GOLO website, it seems less like a comprehensive weight loss program and more like a platform focused on selling a particular supplement called Release. A quick visit to their online store confirms this, as the sole item available for purchase is the Release supplement.

While the website offers some additional resources, including dietary and lifestyle plans, they come with a catch—you can only access them after buying GOLO’s Release supplement.

Now, let’s dive into the evaluation of GOLO’s Release to determine if it’s a worthwhile investment, explore the possibility of finding a more affordable alternative, and provide an overall rating.

Ingredients of GOLO Release

Examining the ingredients is our first step. The recommended dosage is one capsule with each meal, totaling three capsules per day.

GOLO-Release-review-ingredients
Ingredients of GOLO Release supplement.

A significant concern arises when we discover that many of the supplement’s ingredients are concealed within what’s known as a “proprietary blend.” These blends allow companies to keep the exact amounts of each ingredient secret, which can be problematic for consumers.

They hinder transparency by not disclosing the individual doses of ingredients, making it challenging for consumers to assess the effectiveness of the supplement. Companies often use proprietary blends to mask low doses of ingredients in their products. This lack of information makes it difficult for consumers to gauge the potency of the supplement.

Considering these concerns, it’s advisable to steer clear of supplements that utilize proprietary blends. Nevertheless, let’s begin by evaluating what we do know about the ingredients.

Magnesium, zinc, chromium

Let’s break down the ingredients in GOLO Release, starting with magnesium, zinc, and chromium—minerals vital for metabolism. While research suggests that supplementing these minerals may benefit aspects linked to obesity, such as inflammation and insulin sensitivity, they don’t directly lead to weight loss.

These effects are more pronounced in individuals with deficiencies or insulin resistance issues like diabetes or PCOS. If you follow a strict diet, such as keto or veganism, supplementing magnesium or zinc might be beneficial. However, a well-rounded diet rich in vegetables, legumes, nuts, seeds, whole grains, and animal meats usually provides sufficient amounts.

For those without insulin resistance problems and a varied diet, adding these minerals through supplements may not be very helpful. GOLO’s Release, especially the magnesium dose, might fall short, making a regular magnesium citrate supplement a better choice.

Rhodiola

Moving on to Rhodiola, known for cognitive and wakefulness effects, it doesn’t directly impact weight loss but might assist in increasing physical activity.

Unfortunately, we have no info on the dose here, so cannot determine if this will be useful or not.

Inositol

Inositol, like minerals, could enhance insulin sensitivity, especially in individuals with PCOS. However, the inconclusive evidence on its weight loss benefits and the insufficient dose (usually requiring 1-4 grams per day) in the proprietary blend raise concerns.

Berberine, Gardenia, Banaba, Salacia, Apple

The herbs—Berberine, Gardenia, Banaba, Salacia, and Apple—are rooted in traditional use but lack substantial evidence. Their historical purposes include reducing inflammation and aiding insulin resistance. Berberine stands out with some evidence supporting improved insulin sensitivity in diabetes or PCOS. Yet, the doses in studies (1-2 grams per day) far exceed what GOLO Release provides.

GOLO Release Side Effects and Concerns

When exploring the ingredients of GOLO Release, a key concern arises regarding the presence of berberine. While the exact amount remains unclear, berberine has the potential to interact with various medications.

Berberine can influence how the liver processes certain drugs, potentially diminishing their effectiveness or elevating their levels to toxicity when taken alongside other medications. If you’re on medications that undergo liver processing, like cyclosporin, it’s crucial to consult your doctor about the safety of taking GOLO Release.

Moreover, berberine is deemed unsafe during pregnancy or breastfeeding, warranting extra caution for individuals in these situations.

Is GOLO Release effective?

GOLO’s Release seems geared more towards enhancing insulin sensitivity than directly promoting weight loss. For individuals with insulin resistance issues, such as diabetes or PCOS, it might offer theoretical benefits for the condition, even if not really for weight loss.

GOLO-Release-review-ingredient-analysis
GOLO Release supplement ingredient analysis.

However, a more practical approach for addressing insulin resistance could involve dietary changes, such as adopting a low-carb or keto diet. Relying on a supplement with poorly researched herbs might not be as effective as modifying your diet.

Some users report weight loss success with GOLO, but this is likely attributed to the accompanying dietary plan rather than the supplement itself.

Many supplement brands pair their products with dietary plans, as supplements alone typically don’t lead to noticeable weight loss. It’s common for users to credit the supplement for weight loss when, in reality, the dietary plan plays a pivotal role.

This review focuses solely on the effectiveness of the supplement, not the associated diet. Individuals experiencing positive results with GOLO may achieve similar outcomes by following the diet alone, without relying on the supplement.

Overall review: GOLO Release

GOLO-Release-review-overall-summary-rating
Overall GOLO Release review rating.

Reviewing GOLO Release by effectiveness for weight loss, I’m giving it a D. It basically works to support those with insulin resistance issues, not really to help you lose weight. And even if you have insulin resistance issues, taking it without following a proper weight loss diet or lifestyle is not likely going to have any effects on weight whatsoever.

Reviewing GOLO Release by cost, I’m giving it an F. It can be essentially replicated by getting individual ingredients at a cost many times less.

Reviewing GOLO Release for safety, I’m giving it a C. It may not be safe for those taking medications since berberine can interfere with them.

Overall review, I’m giving GOLO Release an F. I would recommend you stay away from it.

Top alternatives to GOLO Release

Overall, GOLO Release is essentially just an overpriced zinc and chromium supplement, with perhaps enough rhodiola to do something, although we really don’t know.

For the other herbal ingredients, the doses obtained from GOLO Release are either too low or lack evidence for benefit, and likely will not have any effect on weight loss.

If you’re looking to achieve similar effects, but better than those of GOLO Release, I would combine a quality rhodiola + berberine + inositol + chromium + zinc.

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Citations

Abdollahi S, Toupchian O, Jayedi A, Meyre D, Tam V, Soltani S. Zinc Supplementation and Body Weight: A Systematic Review and Dose-Response Meta-analysis of Randomized Controlled Trials. Adv Nutr. 2020 Mar 1;11(2):398-411. doi: 10.1093/advances/nmz084. PMID: 31504083; PMCID: PMC7442320.

An Y, Sun Z, Zhang Y, Liu B, Guan Y, Lu M. The use of berberine for women with polycystic ovary syndrome undergoing IVF treatment. Clin Endocrinol (Oxf) 2014;80(3):425-31.

Arentz S, Smith CA, Abbott J, Bensoussan A. Nutritional supplements and herbal medicines for women with polycystic ovary syndrome; a systematic review and meta-analysis. BMC Complement Altern Med. 2017;17(1):500.

Askari M, Mozaffari H, Jafari A, Ghanbari M, Darooghegi Mofrad M. The effects of magnesium supplementation on obesity measures in adults: a systematic review and dose-response meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2021;61(17):2921-2937. doi:10.1080/10408398.2020.1790498

Cahill F, Shahidi M, Shea J, Wadden D, Gulliver W, Randell E, Vasdev S, Sun G. High dietary magnesium intake is associated with low insulin resistance in the Newfoundland population. PLoS One. 2013;8(3):e58278. doi: 10.1371/journal.pone.0058278. Epub 2013 Mar 5. PMID: 23472169; PMCID: PMC3589265.

de Valk HW. Magnesium in diabetes mellitus. Neth J Med. 1999;54(4):139-146. doi:10.1016/s0300-2977(99)00005-4

Fruzzetti F, Perini D, Russo M, Bucci F, Gadducci A. Comparison of two insulin sensitizers, metformin and myo-inositol, in women with polycystic ovary syndrome (PCOS). Gynecol Endocrinol. 2017;33(1):39-42.

Genazzani AD, Prati A, Santagni S, et al. Differential insulin response to myo-inositol administration in obese polycystic ovary syndrome patients. Gynecol Endocrinol. 2012;28(12):969-973. doi:10.3109/09513590.2012.685205

Huang XS, Yang GF, Pan YC. Effect of berberin hydrochloride on blood concentration of cyclosporine A in cardiac transplanted patients. Zhongguo Zhong Xi Yi Jie He Za Zhi 2008;28:702-4.

Khorsandi H, Nikpayam O, Yousefi R, et al. Zinc supplementation improves body weight management, inflammatory biomarkers and insulin resistance in individuals with obesity: a randomized, placebo-controlled, double-blind trial. Diabetol Metab Syndr. 2019;11:101. Published 2019 Dec 2. doi:10.1186/s13098-019-0497-8

Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015;161:69-81.

Onakpoya I, Posadzki P, Ernst E. Chromium supplementation in overweight and obesity: a systematic review and meta-analysis of randomized clinical trials. Obes Rev. 2013;14(6):496-507. doi:10.1111/obr.12026

Piuri G, Zocchi M, Della Porta M, et al. Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes. Nutrients. 2021;13(2):320. Published 2021 Jan 22. doi:10.3390/nu13020320

Rodríguez-Moran M, Guerrero-Romero F. Oral magnesium supplementation improves the metabolic profile of metabolically obese, normal-weight individuals: a randomized double-blind placebo-controlled trial. Arch Med Res. 2014;45(5):388-393. doi:10.1016/j.arcmed.2014.05.003

Sacchinelli A, Venturella R, Lico D, et al. The efficacy of inositol and N-acetyl cysteine administration (Ovaric HP) in improving the ovarian function in infertile women with PCOS with or without insulin resistance. Obstet Gynecol Int 2014;2014:141020.

Tsang C, Taghizadeh M, Aghabagheri E, Asemi Z, Jafarnejad S. A meta-analysis of the effect of chromium supplementation on anthropometric indices of subjects with overweight or obesity. Clin Obes. 2019;9(4):e12313. doi:10.1111/cob.12313

Veronese N, Dominguez LJ, Pizzol D, Demurtas J, Smith L, Barbagallo M. Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials. Nutrients. 2021 Nov 15;13(11):4074. doi: 10.3390/nu13114074. PMID: 34836329; PMCID: PMC8619199.

Veronese N, Watutantrige-Fernando S, Luchini C, et al. Effect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: a systematic review and meta-analysis of double-blind randomized controlled trials [published correction appears in Eur J Clin Nutr. 2016 Dec;70(12 ):1463]. Eur J Clin Nutr. 2016;70(12):1354-1359. doi:10.1038/ejcn.2016.154

Wei, W., Zhao, H., Wang, A., Sui, M., Liang, K., Deng, H., Ma, Y., Zhang, Y., Zhang, H., and Guan, Y. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome. Eur J Endocrinol. 2012;166(1):99-105.

Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72.

Zarezadeh M, Dehghani A, Faghfouri AH, et al. Inositol supplementation and body mass index: A systematic review and meta-analysis of randomized clinical trials. Obes Sci Pract. 2021;8(3):387-397. Published 2021 Oct 22. doi:10.1002/osp4.569

Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93:2559-65.

Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z. Z., Wang, S. K., Zhou, Z. X., Song, D. Q., Wang, Y. M., Pan, H. N., Kong, W. J., and Jiang, J. D. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism 2010;59(2):285-292.


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1 thought on “Doctor Reviews: GOLO Release”

  1. Sir,
    I would like to know, in your opinion, what are the good and effective weight-loss supplements currently available on the market?

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