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Lemme GLP-1 Daily Capsules claim to boost GLP-1 levels, which is important for controlling blood sugar, managing insulin, and curbing appetite. GLP-1 has become popular thanks to weight loss drugs like Ozempic and Wegovy, which stimulate GLP-1 receptors to help people shed pounds. But can Lemme GLP-1 really increase GLP-1 levels and lead to weight loss? The answer isn’t so straightforward.
Ingredients of Lemme GLP-1
Let’s look at the ingredients. You’re advised to take two capsules daily. We’ll explore each ingredient to see if the dosage is effective, if it contains the active compounds necessary for boosting GLP-1, and whether it has the potential to aid in weight loss.
Red Orange Extract
Red orange, also known as blood orange, is a type of orange with a striking deep red color. This red hue comes from anthocyanins, a natural pigment that also offers health benefits. While red orange extracts like Morosil have gained attention for their potential role in weight loss, let’s take a closer look at the facts.
Some early studies involving overweight or obese adults suggest that taking a sweet orange extract daily for six months could lead to slight weight loss. But how much weight are we talking about? Participants using the extract lost around 4.2% of their body weight, compared to 2.2% for those on a placebo. In practical terms, this means the extract only helped people lose about 2% more of their body weight over six months. For someone weighing 140 pounds, that’s less than 3 pounds—an amount many people naturally fluctuate without any effort.
You might be wondering if simply drinking orange juice would have the same effect. Not quite. The key difference is that red orange extracts, such as Morosil, contain concentrated amounts of beneficial flavonoids and anthocyanins, without the sugars found in regular orange juice. In fact, Morosil is made from the “Moro” variety of red oranges, which is particularly high in these compounds. So, just drinking orange juice likely won’t lead to any weight loss.
In fact, a meta-analysis of clinical studies shows that drinking between 250-750 mL of various types of orange juice daily over 2-12 weeks doesn’t result in weight loss when compared to a control group.
Overall, the weight loss effects of red orange extract have been minimal, and it doesn’t appear to affect GLP-1 levels, which are key to appetite control and glucose regulation.
Lemon Fruit Extract
Lemon extract, specifically Eriomin, has been mostly studied for its impact on diabetes management.
In one study, participants with metabolic disease who took Eriomin for 12 weeks experienced a drop in blood glucose and improved insulin resistance. What’s interesting is that their GLP-1 levels also increased by 17%. Another study on individuals with prediabetes showed similar results, with a 15% rise in GLP-1 alongside lower blood glucose levels. However, despite this boost in GLP-1, there was no weight loss observed. In fact, Eriomin didn’t perform any better than a placebo when it came to weight loss.
So, why doesn’t this lemon extract, which increases GLP-1 levels, lead to weight loss like GLP-1 drugs such as Ozempic?
The main reason is that these medications activate GLP-1 receptors far more powerfully. The slight increase in GLP-1 from lemon extract provides only weak stimulation, which isn’t enough to suppress appetite or trigger the weight loss effects you see with stronger drugs. To lose weight, you need a much stronger activation of these receptors—something lemon extract simply can’t deliver.
This modest rise in GLP-1 isn’t exclusive to lemon extract. Other supplements like berberine, curcumin, and cinnamon can also slightly raise GLP-1 levels, but none have consistently suppressed appetite or led to weight loss, especially in people without diabetes.
Saffron extract
Saffron extract has been mainly studied for its effects on metabolic health.
Some research suggests that saffron extract may help lower blood sugar in people with diabetes, though it seems to have little impact on other aspects of diabetes management. In one small study involving older adults with heart disease, saffron extract slightly reduced body mass index (BMI) compared to a placebo.
However, in a study on healthy individuals without diabetes or heart disease, saffron extract didn’t lead to significant weight loss. While it did help reduce snacking, the overall weight reduction was minimal. Reviews of multiple studies indicate that although saffron may have some benefits for metabolic health, its effect on weight loss remains minimal. Furthermore, there’s no evidence that saffron can influence GLP-1 levels in humans.
Is Lemme GLP-1 effective?
Overall, Lemme GLP-1 Daily Capsules are unlikely to lead to significant weight loss.
While some studies on the ingredients suggest minor effects, like reducing snacking or slightly increasing GLP-1 levels, the overall impact on weight is minimal. Even in the few studies showing benefits, the weight loss is small and typically occurs in individuals with metabolic issues.
The product seems to be capitalizing on the rising popularity of GLP-1 medications. “GLP-1” has become a buzzword, with many supplements now claiming to boost GLP-1 for weight loss. However, not all GLP-1-related products deliver the same results. For example, while newer GLP-1 drugs like semaglutide and tirzepatide have shown impressive weight loss outcomes, other GLP-1 agonists, such as Exenatide, don’t typically result in significant weight loss.
Similarly, while the lemon extract in Lemme GLP-1 might slightly raise GLP-1 levels, this small boost doesn’t lead to meaningful weight loss.
Citrus bioflavonoids from fruits like lemons and oranges are known to support metabolism. Research shows that eating more citrus fruits can help with weight control because they are packed with nutrients and compounds that boost metabolism. However, taking a refined extract or supplement is not the same as consuming the whole fruit. Eating the whole fruit, including the fiber, provides a broader range of benefits that a supplement just can’t match.
Overall rating
Rating Lemme GLP-1 by effectiveness for weight loss, I’m giving it a D. It may have some small effects on snacking and blood sugar, but it likely doesn’t have any reliable weight loss effects.
Rating it by cost, I’m giving it a F. Lemme GLP-1 is so expensive you could get real GLP-1 medications for just a little more.
Rating it for safety, I’m giving it a B. It appears to be relatively safe to take.
Overall rating, I’m giving a D. I wouldn’t recommend it at all.
Top alternatives to Lemme GLP-1 Daily Capsules
- Citrus bioflavonoids – 1 to 3 caps / day
- Saffron – 1 cap / day
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Citations
Abedimanesh N, Bathaie SZ, Abedimanesh S, Motlagh B, Separham A, Ostadrahimi A. Saffron and crocin improved appetite, dietary intakes and body composition in patients with coronary artery disease. J Cardiovasc Thorac Res. 2017;9(4):200-208. doi:10.15171/jcvtr.2017.35
Briskey D, Malfa GA, Rao A. Effectiveness of "Moro" Blood Orange Citrus sinensis Osbeck (Rutaceae) Standardized Extract on Weight Loss in Overweight but Otherwise Healthy Men and Women-A Randomized Double-Blind Placebo-Controlled Study. Nutrients. 2022;14(3):427. Published 2022 Jan 18. doi:10.3390/nu14030427
Cardile V, Graziano AC, Venditti A. Clinical evaluation of Moro (Citrus sinensis (L.) Osbeck) orange juice supplementation for the weight management. Nat Prod Res. 2015;29(23):2256-2260. doi:10.1080/14786419.2014.1000897
Cesar TB, Ramos FMM, Ribeiro CB. Nutraceutical Eriocitrin (Eriomin) Reduces Hyperglycemia by Increasing Glucagon-Like Peptide 1 and Downregulates Systemic Inflammation: A Crossover-Randomized Clinical Trial. J Med Food. 2022;25(11):1050-1058. doi:10.1089/jmf.2021.0181
Gout B, Bourges C, Paineau-Dubreuil S. Satiereal, a Crocus sativus L extract, reduces snacking and increases satiety in a randomized placebo-controlled study of mildly overweight, healthy women. Nutr Res. 2010;30(5):305-313. doi:10.1016/j.nutres.2010.04.008
Hancke J, Srivastava S, Caceres DD, Burgos RA, Alarcon P. An exploratory double-blind, randomized, placebo-controlled study to assess the efficacy of CitruSlim on body composition and lipid parameters in obese individuals. Phytother Res. 2021;35(12):7039-7049. doi:10.1002/ptr.7331
Kotanidou EP, Tsinopoulou VR, Giza S, et al. The Effect of Saffron Kozanis (Crocus sativus L.) Supplementation on Weight Management, Glycemic Markers and Lipid Profile in Adolescents with Obesity: A Double-Blinded Randomized Placebo-Controlled Trial. Children (Basel). 2023;10(11):1814. Published 2023 Nov 15. doi:10.3390/children10111814
Milajerdi A, Jazayeri S, Hashemzadeh N, et al. The effect of saffron (Crocus sativus L.) hydroalcoholic extract on metabolic control in type 2 diabetes mellitus: A triple-blinded randomized clinical trial. J Res Med Sci. 2018;23:16. Published 2018 Feb 20. doi:10.4103/jrms.JRMS_286_17
Motallaei M, Ramezani-Jolfaie N, Mohammadi M, Shams-Rad S, Jahanlou AS, Salehi-Abargouei A. Effects of orange juice intake on cardiovascular risk factors: A systematic review and meta-analysis of randomized controlled clinical trials. Phytother Res. 2021;35(10):5427-5439. doi:10.1002/ptr.7173
Ramos FMM, Ribeiro CB, Cesar TB, et al. Lemon flavonoids nutraceutical (Eriomin®) attenuates prediabetes intestinal dysbiosis: A double-blind randomized controlled trial. Food Sci Nutr. 2023;11(11):7283-7295. Published 2023 Sep 19. doi:10.1002/fsn3.3654
Ribeiro CB, Ramos FM, Manthey JA, Cesar TB. Effectiveness of Eriomin® in managing hyperglycemia and reversal of prediabetes condition: A double-blind, randomized, controlled study. Phytother Res. 2019;33(7):1921-1933. doi:10.1002/ptr.6386
Tahmasbi F, Araj-Khodaei M, Mahmoodpoor A, Sanaie S. Effects of saffron (Crocus sativus L.) on anthropometric and cardiometabolic indices in overweight and obese patients: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2022;36(9):3394-3414. doi:10.1002/ptr.7530
Wang X, Li D, Liu F, Cui Y, Li X. Dietary citrus and/or its extracts intake contributed to weight control: Evidence from a systematic review and meta-analysis of 13 randomized clinical trials. Phytother Res. 2020;34(8):2006-2022. doi:10.1002/ptr.6673
Yaribeygi H, Jamialahmadi T, Moallem SA, Sahebkar A. Boosting GLP-1 by Natural Products. Adv Exp Med Biol. 2021;1328:513-522. doi:10.1007/978-3-030-73234-9_36
Attributions
Functions of GLP-1 By Lthoms11 – Own work, CC BY-SA 4.0, https://en.wikipedia.org/w/index.php?curid=55236027
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