Best Supplements for Tinnitus? What the Research Says

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Tinnitus can be frustrating to deal with, especially because it isn’t just one condition with a single cause. In reality, it is a symptom that can arise from several different processes involving the ears, the brain, the jaw, the neck, blood vessels, medications, or broader health conditions. Two people may hear exactly the same ringing sound but have very different reasons for experiencing it. Likewise, the same person may have several contributing factors at once.

This matters because the most useful approach to tinnitus depends on what is causing it, whether an underlying condition can be treated, and how much the symptoms interfere with everyday life. You might address one contributing factor and still experience tinnitus because another factor remains. Alternatively, the original cause may no longer be active, but the brain’s response to the sound may continue.

That is why, when discussing the best supplements for tinnitus, one of the most important questions to ask is: what is actually causing it in your case? A supplement that corrects a genuine nutrient deficiency may be useful for someone with that deficiency, whereas the same product may accomplish very little for someone whose tinnitus is related to hearing loss or jaw dysfunction.

It is also important to separate three different goals: preventing further ear damage, treating an underlying medical problem, and reducing how noticeable or distressing tinnitus feels. These goals are not interchangeable. A supplement that appears to protect hearing in a particular research setting has not necessarily been shown to reduce existing tinnitus, and something that helps with sleep does not necessarily reduce the underlying auditory sensation.

Understanding Tinnitus: What Is Actually Happening?

Tinnitus is the perception of sound when there is no corresponding external sound source. People describe it in many ways, including ringing, buzzing, hissing, whistling, humming, clicking, roaring, or a high-pitched electronic tone. It may affect one ear, both ears, or seem to come from somewhere inside the head. Some people experience it constantly, while others notice it only in certain environments or at particular times of day.

Most tinnitus is subjective, meaning that only the affected person can hear it. This makes it different from a sound generated inside the body, such as certain blood-flow noises or muscular movements, which may sometimes be detected by an examiner. The distinction matters because different types of tinnitus can require different investigations.

One common misconception is that tinnitus always means the ears are physically producing a ringing sound. In most cases, that is not what is happening. Tinnitus is better understood as a perception generated by the auditory system, sometimes following changes in the ear’s ability to transmit sound and sometimes involving altered activity in the brain’s sound-processing networks.

For example, when hearing declines, the brain receives less information from certain sound frequencies. Changes in the way the auditory system processes and compensates for this reduced input may contribute to tinnitus. However, this is not the only possible mechanism, and scientists have not established a single explanation that accounts for every case.

Another important distinction is that tinnitus loudness and tinnitus distress are not the same thing. Someone may hear a relatively loud tone but find it only mildly annoying, while another person may experience a quieter sound that severely interferes with concentration, sleep, or emotional well-being. The brain’s attention, stress response, and interpretation of the sound can influence how intrusive it becomes.

This helps explain why effective tinnitus management does not always require eliminating the sound completely. For many people, meaningful improvement means becoming less bothered by it, sleeping better, concentrating more easily, and returning to normal activities without constantly monitoring the ringing.

When Should You Get Tinnitus Checked?

Although tinnitus is often associated with non-emergency conditions, it should not automatically be dismissed as harmless. Certain patterns can indicate a problem that needs prompt medical assessment. In particular, sudden hearing loss developing over a short period, especially within 72 hours, requires urgent same-day medical evaluation. Do not wait to see whether a supplement helps or assume that the hearing change will resolve on its own.

Tinnitus accompanied by new neurological symptoms, such as facial weakness, difficulty speaking, or sudden loss of coordination, also requires emergency assessment. Sudden severe dizziness or other new symptoms can warrant urgent evaluation, particularly when they occur alongside a hearing change.

Tinnitus that repeatedly affects only one ear, produces a sound that follows the heartbeat, or occurs alongside noticeably different hearing between the ears deserves medical investigation even when there are no other symptoms. These patterns do not automatically mean something dangerous is present, but they can indicate an underlying cause that should not be overlooked.

For persistent tinnitus, a healthcare professional can examine the ears, review medications, assess related symptoms, and arrange a hearing evaluation. Imaging tests are not necessary for everyone with tinnitus, but they may be appropriate when particular features suggest an underlying structural, vascular, or neurological problem.

The general principle is straightforward: identify the cause before spending time and money trying to suppress the symptom. A person with earwax obstruction, a hearing problem, or a medication-related reaction may benefit far more from addressing that issue than from experimenting with multiple supplements.

Causes of Tinnitus

In general, tinnitus causes fall into several major categories. These include hearing loss or inner ear damage, problems in the ear canal or middle ear, medication side effects, jaw and neck dysfunction, neurological conditions, vascular issues, and broader metabolic or systemic imbalances. More than one category may apply to the same individual, and identifying every contributing factor is not always possible.

With that in mind, it helps to think about tinnitus supplements in two ways. Some have been investigated for their potential to influence tinnitus symptoms directly, while others may support a related health issue, such as a nutrient deficiency, migraine, sleep disturbance, or metabolic disorder. The second category can be useful in the right circumstances, but that does not automatically make the supplement an effective tinnitus treatment.

There is an important limitation to keep in mind throughout this discussion: no dietary supplement has been established as a reliable cure for tinnitus. The evidence for commonly promoted products is generally limited, inconsistent, or dependent on a very specific patient population. The American Academy of Otolaryngology–Head and Neck Surgery Foundation’s 2026 clinical practice guideline recommends against using dietary supplements as the primary treatment for persistent, bothersome tinnitus.

supplements-for-tinnitus — Researched supplements for different causes of tinnitus

Hearing Loss and Cochlear Damage

One of the most common causes of tinnitus is hearing loss or damage to the inner ear, particularly the cochlea. The cochlea contains thousands of microscopic sensory hair cells that convert sound vibrations into electrical signals for the brain. These cells can be damaged by aging, repeated exposure to loud noise, certain medications, infections, and other conditions affecting the inner ear.

When the auditory system receives less sound information than usual, changes in its processing may contribute to the perception of sound even when no external sound is present. Scientists often discuss this in terms of changes in neural activity, reduced auditory input, and altered sensitivity to sound. The popular explanation that the brain simply turns up its internal volume is a useful simplification, but the actual biology is more complicated.

Hearing-related tinnitus is often described as a high-pitched ringing, whistle, or tone. It can affect both ears, particularly after prolonged noise exposure or age-related hearing loss, but it may also occur in one ear. The pitch, location, and loudness of the sound vary considerably, so tinnitus cannot be classified reliably based on its description alone.

Some people assume they have normal hearing because they can follow conversations without difficulty. However, mild or frequency-specific hearing loss may go unnoticed, especially when it affects frequencies that are not essential for everyday conversation. A hearing test can reveal changes that would otherwise be missed and help determine whether hearing loss may be contributing to tinnitus.

Noise exposure is particularly important because damage from loud sound can occur even when temporary symptoms, such as ringing or muffled hearing, eventually disappear. Repeated exposure may gradually increase the risk of permanent hearing loss and persistent tinnitus. Sensible hearing protection in genuinely noisy environments, taking breaks from loud sound, and keeping headphones at reasonable listening levels are therefore more established preventive measures than relying on an antioxidant supplement after exposure.

When tinnitus is associated with hearing loss, the evidence for supplements is generally weak. Several products have attracted research interest, but their results need to be considered carefully. A study suggesting improvement in a secondary symptom, a small reduction in a questionnaire score, or protection against future hearing damage does not establish that a supplement can reverse cochlear injury or reliably eliminate existing tinnitus.

Melatonin for Tinnitus and Sleep Problems

Melatonin is a hormone involved in regulating the body’s sleep-wake cycle. Because tinnitus can become especially noticeable at night, when the surrounding environment is quiet, melatonin has attracted interest as a possible way to improve sleep and reduce the burden associated with ringing in the ears.

Small clinical studies have reported improvements in sleep disturbances associated with tinnitus, and some have also suggested improvements in tinnitus-related symptom scores. However, the trials have methodological limitations, and the overall evidence does not establish melatonin as a reliable treatment for the tinnitus sensation itself.

This distinction is important. If someone falls asleep more easily and feels less exhausted during the day, tinnitus may become less distressing even if the perceived ringing has not changed substantially. That can still be a meaningful benefit, but it should not be confused with repairing damage to the inner ear or eliminating the source of the sound.

For people whose primary problem is difficulty sleeping because of tinnitus, it is worth addressing sleep habits, evening routines, stress, and the bedroom environment. Persistent insomnia may warrant professional assessment. Melatonin is not suitable for everyone, can cause unwanted effects such as next-day drowsiness, and may interact with medications. Its use should therefore be discussed with a healthcare professional rather than treated as an automatic solution for tinnitus.

CoQ10 and Age-Related Hearing Loss

Coenzyme Q10, commonly called CoQ10, helps cells produce energy and participates in antioxidant processes. Since the inner ear has substantial energy requirements, researchers have investigated whether CoQ10 supplementation might help people experiencing age-related hearing changes and associated tinnitus.

A small randomized clinical trial published in 2025 examined CoQ10 as an addition to routine treatment in 50 people with tinnitus associated with presbycusis, or age-related hearing loss. The researchers reported improvements in tinnitus-related disability and sleep disturbance, along with reductions in some measures of tinnitus loudness. However, the results were not equally convincing across all outcomes, and the small sample limits how confidently they can be generalized to other people with tinnitus.

This is an interesting preliminary finding, not proof that CoQ10 works for tinnitus in general. The results need to be replicated in larger, well-designed trials, and there is no established evidence that taking CoQ10 reverses age-related hearing loss. At present, it is best considered an experimental option rather than an established tinnitus supplement.

Panax Ginseng for Chronic Tinnitus

Panax ginseng, sometimes called Asian or Korean ginseng, has been studied for its potential effects on fatigue, cognitive function, and other aspects of health. It also contains compounds that have attracted interest for their possible antioxidant and biological effects. These mechanisms have led researchers to investigate whether ginseng might help people with chronic tinnitus.

One small, open-label pilot study examined Korean red ginseng in 61 people with chronic tinnitus over four weeks. Participants received different amounts of ginseng or a ginkgo biloba comparison treatment. The higher-ginseng group showed an improvement in a measure of tinnitus-related disability, but the study did not find statistically significant improvements in the visual analogue ratings of tinnitus severity across the treatment groups.

The study is interesting because it provides a preliminary human signal worth investigating. However, it was short, lacked a placebo group, and was not designed to establish whether ginseng consistently reduces tinnitus. The results therefore do not justify strong claims that ginseng is an effective tinnitus treatment.

Ginseng can also interact with medications and may affect sleep, blood glucose, or blood clotting. Anyone considering it should review potential interactions with a healthcare professional, especially when taking diabetes medications, anticoagulants, or other regular prescriptions.

Magnesium and Noise-Related Ear Damage

Magnesium is important for normal nerve function, muscle function, and many cellular processes. Researchers have investigated its possible role in the response of the inner ear to loud noise, partly because magnesium is involved in mechanisms that influence blood flow and cellular stress.

Some studies have explored magnesium supplementation for reducing hearing damage associated with noise exposure. This is a different question from whether magnesium can reduce tinnitus that is already established. Even if a nutrient helps limit damage under certain experimental or clinical conditions, it does not follow that the same nutrient can reverse damage after it has occurred.

Clinical evidence for magnesium as a direct treatment for persistent tinnitus remains insufficient. A person with low magnesium intake or a medically confirmed deficiency should address that issue, but taking additional magnesium without a deficiency has not been shown to reliably eliminate tinnitus. Magnesium may have a more relevant role when someone also experiences migraines, a condition for which it has been studied separately.

Supplemental magnesium can cause diarrhea and abdominal discomfort, depending on the formulation and amount. People with impaired kidney function need particular caution because the kidneys normally help regulate magnesium levels. It can also interfere with the absorption of certain antibiotics and other medications, so timing and suitability should be reviewed with a pharmacist or clinician.

Vitamin B12 and Tinnitus

Vitamin B12 is necessary for normal nerve function and the formation of healthy blood cells. A deficiency can produce neurological problems, including numbness, tingling, weakness, and difficulties with balance or memory. Researchers have also investigated possible associations between low B12 levels, hearing difficulties, and tinnitus.

Some observational studies have found that B12 deficiency occurs more frequently in certain groups of people with tinnitus. However, an association does not prove that the deficiency caused the tinnitus, and clinical studies have not demonstrated consistent benefits from giving B12 to people whose levels are already adequate.

If a person has a genuine B12 deficiency, correcting it is important regardless of whether it improves tinnitus. The appropriate treatment depends on the severity and cause of the deficiency, including whether the problem involves diet, absorption, or another medical condition. Oral supplementation can be appropriate in many cases, while injections may be indicated in particular circumstances. There is no general evidence that B12 injections are inherently more effective than oral supplements for treating tinnitus.

In other words, B12 is best viewed as a targeted treatment for a deficiency rather than a universal tinnitus supplement. Testing is particularly worth discussing with a healthcare professional when symptoms or risk factors suggest a possible deficiency.

Vitamin D and Tinnitus

Vitamin D has also been investigated because some studies have reported an association between low vitamin D levels and tinnitus. Vitamin D plays important roles in bone health, muscle function, and other biological processes, which has led researchers to explore whether inadequate levels could be related to aspects of auditory health.

The major limitation is that people with tinnitus having lower vitamin D levels does not prove that vitamin D deficiency caused their symptoms. Differences in age, general health, outdoor activity, diet, and other factors can influence both vitamin D status and the likelihood of developing hearing problems.

There is not enough evidence to recommend vitamin D supplements as a direct treatment for tinnitus in people whose levels are normal. If a deficiency is identified or there are reasons to suspect one, correcting it may be appropriate for general health. However, supplementing beyond what is needed has not been established as a reliable way to silence tinnitus.

N-Acetylcysteine (NAC) and Prevention of Noise-Induced Hearing Loss

N-acetylcysteine, or NAC, helps the body produce glutathione, an antioxidant involved in protecting cells from oxidative stress. Because intense noise exposure can trigger several forms of cellular stress within the cochlea, NAC has been investigated as a possible way to reduce noise-related hearing damage.

Some research is encouraging but far from conclusive. A systematic review and meta-analysis of five randomized clinical trials involving 1,115 participants found modest benefits on certain measures of hearing-threshold changes after noise exposure. However, the evidence varied across sound frequencies, and a large randomized trial in military personnel did not find a significant benefit for its primary hearing-loss outcome.

These findings are relevant to the prevention of noise-induced hearing damage, but they should not be interpreted as proof that NAC treats chronic tinnitus. Preventing some injury before or around a particular exposure and reversing an established auditory condition are very different goals. It is also not established that taking NAC reliably prevents future tinnitus in everyday life.

NAC has legitimate medical uses, but supplementing with it to protect the ears should not replace hearing protection or workplace noise-safety measures. It can also cause gastrointestinal side effects and may interact with certain medications, including nitroglycerin. Anyone considering it for a medical purpose should discuss the potential benefits and risks with a qualified healthcare professional.

Pycnogenol for Tinnitus Associated With Ménière’s Disease

Pycnogenol is a branded extract of French maritime pine bark that contains various plant compounds. It has been investigated for potential effects on blood vessel function and circulation. This has prompted interest in its use for selected inner ear conditions, including Ménière’s disease, which can involve episodes of vertigo, hearing changes, ear fullness, and tinnitus.

A clinical registry study involving people with Ménière’s disease and tinnitus reported greater improvements in several symptoms among participants who received Pycnogenol alongside usual management than among those who received usual management alone. However, the study was not a rigorous randomized, blinded, placebo-controlled trial. Differences between the groups, expectations, and other aspects of study design could have influenced the findings.

As a result, these findings are preliminary. They do not establish Pycnogenol as an effective treatment for Ménière’s disease or show that it works for tinnitus caused by other conditions. Anyone experiencing recurrent vertigo, fluctuating hearing, or ear pressure should receive appropriate medical assessment rather than relying on a circulation-oriented supplement.

Ginkgo Biloba for Tinnitus

Ginkgo biloba is one of the most heavily marketed herbal supplements for tinnitus. It is often promoted on the premise that improving circulation to the brain or inner ear will reduce ringing and restore normal auditory function. Although ginkgo contains compounds that influence various biological processes, a plausible mechanism is not the same as demonstrated clinical effectiveness.

Systematic reviews of clinical trials have not found convincing evidence that ginkgo consistently improves tinnitus when tinnitus is the primary complaint. Some studies have reported benefits, but the overall literature includes differences in study populations, formulations, outcome measures, and quality. The possibility of a placebo response also makes it particularly important to use well-designed studies when evaluating a subjective symptom such as ringing in the ears.

There is consequently little reason to assume that ginkgo will work simply because a product is advertised specifically for tinnitus. It should not be considered an established treatment, and people taking blood thinners or other medications that affect bleeding should be particularly careful because ginkgo may increase bleeding risk.

Zinc for Tinnitus

Zinc is essential for immune function, normal cellular activity, and many enzymes. Because zinc has several roles in the nervous system and general health, researchers have investigated whether zinc supplementation could help people with tinnitus, particularly those with low zinc levels.

However, clinical trials in adults with tinnitus have generally failed to show convincing benefits from zinc supplementation compared with placebo. Correcting a genuine zinc deficiency is important, but that does not mean taking extra zinc will improve tinnitus in a person whose zinc status is already adequate.

Excessive zinc supplementation can cause nausea and other gastrointestinal symptoms. Taking high amounts over time can also interfere with copper absorption and lead to copper deficiency, which may cause additional health problems. Zinc should therefore be used to address a demonstrated or reasonably suspected nutritional need rather than as a default tinnitus remedy.

Overall, hearing-related tinnitus remains a difficult condition to treat, and supplements have not provided a reliable solution. The most useful approach is often a combination of hearing assessment, appropriate hearing care, protection against further noise damage, and strategies to reduce tinnitus-related distress. Supplements may have a limited supporting role when a separate, treatable deficiency or medical issue is present.

External and Middle Ear Disorders

Another common cause of tinnitus involves problems in the ear canal or middle ear, which can interfere with the normal transmission of sound. Examples include earwax buildup, inflammation of the ear canal, middle ear infections, fluid behind the eardrum, and some forms of eardrum or middle ear dysfunction.

These conditions may also produce a sensation of pressure, fullness, muffled hearing, discomfort, or a feeling that the ear is blocked. Tinnitus associated with these problems may be temporary, persistent, or intermittent, depending on the cause. Although symptoms may affect one ear more than the other, the pattern alone cannot establish the diagnosis.

The encouraging news is that certain external and middle ear problems have specific treatments. A healthcare professional can determine whether earwax needs to be removed, an infection requires treatment, or another problem is interfering with normal hearing. When the underlying issue resolves, the tinnitus may also improve or disappear.

This is one of the clearest examples of why identifying the cause matters more than choosing a supplement. If earwax is blocking the canal, taking ginkgo, magnesium, or a multivitamin is unlikely to address the blockage. If an infection or other treatable ear condition is responsible, appropriate clinical management is more relevant than an antioxidant supplement.

It is important not to insert cotton swabs or other objects deeply into the ear canal in an attempt to remove wax, since this can push the wax farther inward or injure the ear. Similarly, ear drops are not appropriate for every person, particularly when there may be a perforated eardrum or a history of ear surgery. A clinician can help determine the safest option.

Sudden hearing changes, persistent discharge, significant ear pain, or pronounced dizziness should not simply be attributed to wax or pressure without assessment. These symptoms can indicate a condition that needs prompt attention.

Medication- and Substance-Induced Tinnitus

Tinnitus can sometimes develop as a side effect of medication or exposure to certain substances. Some drugs affect the auditory system directly, while others can cause hearing damage under particular circumstances. This is commonly described as medication-induced or, when hearing structures are damaged, drug-related ototoxicity.

Examples include high doses of aspirin, some other pain relievers, certain antibiotics, specific diuretics, and some chemotherapy medicines such as cisplatin. The likelihood of developing tinnitus depends on the particular drug, the amount taken, the duration of treatment, kidney function, existing hearing problems, and other risk factors. Not everyone taking these medications develops auditory symptoms, and not every episode of tinnitus in someone taking a medication is necessarily caused by that medication.

A change in medication dose or the introduction of a new drug can provide an important clue, especially when the timing closely matches the onset of tinnitus. However, symptoms can sometimes appear gradually, and some medications may affect hearing even when tinnitus is not the first symptom noticed.

If you suspect that a medication is contributing to tinnitus, contact the prescribing healthcare professional or pharmacist to review the timing, dose, alternatives, and available monitoring. Do not stop a prescribed medication or reduce the dose on your own. In certain situations, abruptly discontinuing treatment may be dangerous, and the benefits of the medication may outweigh the potential auditory risks.

Some people also notice changes in tinnitus after drinking alcohol, consuming caffeine, or using nicotine. However, the evidence is not strong enough to say that these substances universally cause tinnitus or that everyone with tinnitus must avoid them. Responses vary, and other factors, including sleep disruption, blood pressure changes, anxiety, and general health, may influence what a person notices.

For this reason, it is more useful to look for a consistent individual pattern than to assume a particular food, drink, or substance is responsible. A brief record of tinnitus severity, sleep, stress, medication changes, and relevant exposures may help identify patterns without making unnecessary dietary restrictions.

Can Supplements Protect the Ears From Medication Damage?

Several antioxidant and nutrient supplements have been investigated for their possible role in reducing hearing injury associated with medications or other exposures. NAC is one example, and vitamins such as vitamin E have also attracted research interest. However, results from laboratory experiments or small clinical studies do not establish that taking these products reliably prevents medication-induced hearing loss in routine medical practice.

There is no established supplement regimen that can be relied upon to prevent all forms of medication-related ototoxicity. The effects can differ considerably between drugs, and evidence for one specific exposure cannot automatically be applied to another. Some supplements may also interact with the medication being used to treat the underlying illness.

For example, someone receiving a potentially ototoxic antibiotic or chemotherapy medicine should ask the treating team whether hearing monitoring, a medication adjustment, or another protective strategy is appropriate. Adding supplements without that discussion can create unnecessary risks without providing proven protection.

In short, preventing or limiting a known medication-related risk requires an individualized medical plan. Supplements should not be used as a substitute for appropriate prescribing decisions, monitoring, or follow-up.

TMJ and Neck-Related Tinnitus

Tinnitus does not always originate from an isolated problem in the ear. It can also be influenced by the jaw, neck muscles, and sensory nerves that communicate with the auditory system. This is often called somatosensory tinnitus, a term describing tinnitus whose perception can be influenced by input from structures outside the auditory system.

Potential contributors include temporomandibular joint dysfunction, teeth grinding or clenching, jaw muscle tension, neck pain, and certain movement-related disorders. Some people notice that their tinnitus changes when they open their mouth, clench their teeth, turn their head, or move their neck. Others experience jaw pain, clicking, headaches, or restricted jaw movement alongside the ringing.

Changes in tinnitus during jaw or neck movement can be a useful clinical clue, but they do not prove that the jaw or neck is the only cause. Many people with hearing-related tinnitus can also change the perceived pitch or loudness through movement. A proper assessment helps determine whether a musculoskeletal problem is genuinely contributing to the symptoms.

When a jaw or neck problem is identified, treatment may involve addressing teeth grinding, improving jaw function, treating pain, or using appropriate physiotherapy. Management should be based on the actual problem rather than on the assumption that every case of tinnitus requires dental treatment or neck manipulation.

Supplements have not been established as direct treatments for somatosensory tinnitus. Some may help with related issues in specific circumstances, but this is different from treating the underlying jaw or neck dysfunction.

Melatonin, Vitamin D, and Jaw-Related Symptoms

Melatonin has been studied in relation to sleep, pain, and certain symptoms associated with temporomandibular disorders. However, evidence for these uses is limited, and any improvement in jaw-related pain would not automatically establish that melatonin treats tinnitus.

Vitamin D has also been investigated in relation to musculoskeletal health and certain jaw conditions. Low vitamin D status may be associated with a range of health problems, but there is insufficient evidence to conclude that vitamin D supplementation reliably reduces teeth grinding or resolves jaw-related tinnitus. Correcting a confirmed deficiency may be appropriate for general health without necessarily changing the ringing.

For people whose symptoms appear to involve the jaw or neck, identifying and treating the mechanical problem is generally more directly relevant than taking supplements. Persistent pain, difficulty opening the mouth, or significant neck symptoms should be evaluated by an appropriately qualified healthcare professional.

Neurological Causes of Tinnitus

The auditory system is closely connected to other parts of the nervous system, which means that tinnitus can sometimes occur alongside neurological conditions. Examples include migraine disorders, head injuries such as concussions, and certain neurological diseases. These conditions may influence sound processing, sensory sensitivity, balance, concentration, or the way tinnitus is experienced.

Neurological symptoms accompanying tinnitus can vary considerably. Someone with migraine may experience tinnitus alongside headaches, sensitivity to light, nausea, dizziness, or other sensory symptoms. After a head injury, tinnitus may occur alongside changes in concentration, balance, sleep, mood, or sensitivity to sound. However, these symptoms are not specific enough to establish a diagnosis without appropriate assessment.

Migraine is particularly relevant because it can affect more than just the head pain usually associated with the condition. Some people experience ear pressure, sound sensitivity, dizziness, or changes in tinnitus around migraine episodes. Treating migraine may improve these associated symptoms in some individuals, but this does not mean that every case of tinnitus accompanied by a headache is caused by migraine.

New tinnitus after a head injury deserves medical assessment, particularly if it is accompanied by hearing changes, substantial dizziness, persistent headaches, confusion, or other neurological symptoms. Sudden neurological changes or severe symptoms should be assessed urgently rather than managed with supplements at home.

Magnesium and Migraine-Associated Tinnitus

Magnesium has been investigated as a possible aid for migraine prevention. Some clinical evidence supports its use in selected people with migraine, although the strength of the evidence and the most appropriate formulation vary. This makes magnesium potentially relevant to someone who experiences both migraine and tinnitus, provided migraine is an established part of the clinical picture.

The key limitation is that evidence for magnesium in migraine does not establish that it directly treats tinnitus. If treating migraine reduces related sound sensitivity or makes episodes less disruptive, tinnitus may also become less bothersome. But this is an indirect and situation-specific benefit rather than proof of a general tinnitus effect.

Anyone considering magnesium for migraine prevention should discuss the choice of formulation and suitability with a healthcare professional. Higher supplemental amounts are not automatically more effective, and magnesium may cause gastrointestinal symptoms or interact with certain medications.

Melatonin and Migraine-Associated Tinnitus

Melatonin has also been studied for migraine prevention, partly because sleep and circadian rhythms can influence migraine patterns. Research has produced some promising findings, but the evidence is not sufficient to assume that melatonin will prevent migraines in every individual or that it will reduce tinnitus directly.

When migraine, insomnia, and tinnitus occur together, it is useful to address each problem according to the evidence for that condition. A treatment that improves sleep may reduce fatigue and make tinnitus easier to manage, while effective migraine management may reduce related episodes of sensory discomfort. Neither outcome necessarily indicates that the supplement has removed the underlying tinnitus.

Supplements After a Concussion or Head Injury

Various supplements, including Panax ginseng and antioxidant products, have been investigated for their potential effects on aspects of brain health. However, evidence that these supplements improve selected outcomes following a head injury does not establish that they treat post-traumatic tinnitus.

There is currently no established supplement regimen that reliably resolves tinnitus following a concussion. Recovery depends on the nature of the injury and the symptoms involved, and appropriate management may include medical follow-up, assessment of hearing and balance, and rehabilitation for persistent symptoms.

In this setting, the priority should be identifying the consequences of the injury and treating them appropriately. Supplements marketed for brain recovery should not replace medical assessment or be assumed to accelerate recovery simply because they have antioxidant or anti-inflammatory effects in laboratory studies.

Vascular (Pulsatile) Tinnitus

Vascular tinnitus is a distinct form of tinnitus in which the sound follows the heartbeat. People often describe it as a pulsing, throbbing, or whooshing noise. It may be continuous or intermittent and can be particularly noticeable in quiet surroundings or when lying down.

Unlike the more common forms of subjective tinnitus, pulsatile tinnitus may be associated with blood-flow changes or structures near the ear. Possible causes include certain abnormalities of blood vessels, changes in blood pressure, raised intracranial pressure, and other conditions affecting circulation or the structures surrounding the auditory system. Some causes are relatively benign, while others require specific investigation and treatment.

Pulsatile tinnitus should not automatically be attributed to high blood pressure or poor circulation. The fact that a sound follows the heartbeat provides an important diagnostic clue, but it does not reveal the underlying cause by itself.

This is also a situation in which supplements are particularly inappropriate as a first response. Products promoted for circulation or vascular health cannot be assumed to correct the cause of pulsatile tinnitus, and trying to manage it with supplements may delay assessment of an underlying condition.

Anyone experiencing persistent or newly developed heartbeat-synchronous tinnitus should seek medical assessment. A healthcare professional can decide whether hearing tests, blood pressure assessment, imaging, or other investigations are needed. Do not press on the blood vessels in your neck or perform other self-tests to try to determine the cause.

If pulsatile tinnitus occurs alongside sudden neurological symptoms, a sudden severe headache, new visual disturbances, or other acute concerning symptoms, urgent medical assessment is especially important. The aim is to identify the cause rather than simply suppress the sound.

Metabolic and Systemic Causes of Tinnitus

Tinnitus can also occur alongside broader health conditions that affect the entire body. These include thyroid disorders, iron deficiency or anemia, vitamin B12 deficiency, diabetes, and certain other conditions that influence circulation, nerve function, or general metabolic health.

These relationships are not always straightforward. A medical condition may directly contribute to the symptoms, indirectly affect hearing, or simply occur at the same time as tinnitus for an unrelated reason. Finding a health condition in someone with tinnitus does not automatically prove that it is responsible, so investigation should be guided by the symptoms, history, examination, and other relevant risk factors.

Iron deficiency and anemia are particularly relevant in the evaluation of people with fatigue, shortness of breath, pallor, or other suggestive symptoms. Some cases of anemia can be associated with pulsatile tinnitus, but tinnitus alone does not establish iron deficiency. Unnecessary iron supplementation can cause adverse effects and may be harmful in people who do not need additional iron.

Thyroid disorders can affect many body systems, and abnormal thyroid function may sometimes coexist with hearing symptoms or changes in general well-being. Similarly, diabetes can contribute to nerve and blood vessel problems, although the relationship between diabetes and tinnitus is complex. These conditions should be evaluated and treated according to their established medical indications.

If a specific abnormality is identified, correcting it may improve overall health and may help tinnitus when the two are genuinely related. However, improvement cannot be guaranteed, and correcting a laboratory value is not the same as directly treating the auditory mechanisms responsible for persistent tinnitus.

Alpha-Lipoic Acid and Diabetes-Related Tinnitus

Alpha-lipoic acid is a compound involved in energy metabolism that has also been studied for its antioxidant properties. It has attracted interest in diabetes research, particularly because oxidative stress and nerve dysfunction can contribute to certain diabetic complications.

Some preliminary research has explored alpha-lipoic acid in people with diabetes who also experience auditory symptoms. However, the evidence is limited, and it is not sufficient to establish alpha-lipoic acid as an effective treatment for diabetes-related tinnitus or to show that it reliably improves hearing.

Its potential relevance should therefore be considered separately from its more general marketing claims about nerve health or antioxidant protection. A person with diabetes should prioritize established approaches to managing blood glucose, cardiovascular risk, and other complications rather than assuming that alpha-lipoic acid will protect the ears or eliminate tinnitus.

Alpha-lipoic acid can also affect blood glucose levels and may increase the risk of hypoglycemia when combined with certain diabetes medications. Its use should be discussed with the treating healthcare professional, particularly when glucose-lowering treatment is involved.

Panax Ginseng and Metabolic Health

Panax ginseng has been studied for possible effects on blood glucose regulation and other measures of metabolic health. However, results vary, and it should not be considered a replacement for established treatment of diabetes, hypertension, or abnormal cholesterol levels.

Even if a supplement has a modest effect on a metabolic marker in a particular population, it does not follow that it will improve tinnitus. The proposed chain of reasoning must be supported by studies that actually measure tinnitus outcomes, not just blood pressure, glucose, circulation, or antioxidant activity.

For that reason, ginseng’s potential metabolic effects should not be used as evidence that it treats tinnitus caused by diabetes or vascular disease. Any use alongside prescription medication should be reviewed for safety and possible interactions.

Pycnogenol and Circulation-Related Claims

Pycnogenol has also been studied for possible effects on blood vessel function and certain cardiovascular or metabolic measures. These findings are sometimes used to suggest that it may help tinnitus by improving circulation to the inner ear. However, a proposed circulation-related mechanism is not enough to establish clinical benefit.

As discussed earlier, the research involving tinnitus and Ménière’s disease includes preliminary findings that require confirmation. It would be inappropriate to generalize these results to everyone with tinnitus or to conclude that Pycnogenol can treat tinnitus caused by diabetes, high blood pressure, or other systemic conditions.

For people with suspected vascular or metabolic contributors, medical assessment and appropriate treatment of the underlying condition are more important than trying to improve circulation with a supplement. Blood pressure, diabetes, thyroid function, and nutritional deficiencies should be managed according to established clinical evidence and the needs of the individual.

How to Interpret the Evidence for Tinnitus Supplements

One reason tinnitus supplements can be difficult to evaluate is that studies often investigate very different outcomes. A research trial might measure how loud tinnitus seems, how much it interferes with daily activities, whether sleep improves, or whether hearing thresholds change after noise exposure. These are related outcomes, but they are not interchangeable.

For example, a supplement that improves sleep may reduce the amount of time someone spends worrying about tinnitus at night. That is a worthwhile result, but it does not necessarily mean the perceived ringing became quieter. Similarly, a supplement that modestly reduces hearing-threshold changes after noise exposure has not necessarily been shown to treat established tinnitus.

The quality of a study matters just as much as the outcome being measured. Small studies can produce apparently large effects by chance. Studies without a proper placebo group may be influenced by expectations, natural symptom fluctuations, or changes in other treatments. Results from an uncontrolled registry are generally less convincing than findings from a well-designed, randomized, blinded clinical trial.

The population being studied is another important consideration. A supplement that has been investigated in a small group of patients with a particular disease should not automatically be recommended to everyone with tinnitus. Someone with a confirmed nutrient deficiency, for example, is not equivalent to someone with normal nutrient levels and tinnitus associated with longstanding hearing loss.

Finally, statistical significance does not necessarily mean that patients experience a meaningful improvement. A study may report a numerical difference between groups, but the difference could be small, inconsistent across outcomes, or too uncertain to guide treatment. Useful research should ideally show that an intervention provides a meaningful benefit that can be replicated in independent studies.

These considerations explain why a long ingredient list, a complicated antioxidant formula, or a supplement with an impressive biological mechanism cannot substitute for clinical evidence. The most useful question is not whether a product contains ingredients that affect the nervous system or circulation. It is whether the finished product has been shown to produce a meaningful improvement in people with the relevant type of tinnitus.

What Helps Tinnitus Beyond Supplements?

Because supplements have not demonstrated reliable benefits for persistent tinnitus, it is worth understanding the approaches that have stronger support. These approaches do not necessarily eliminate the sound, but they can make a substantial difference to hearing, sleep, concentration, and quality of life.

Hearing Assessment and Hearing Aids

A hearing evaluation can help determine whether hearing loss is contributing to tinnitus, including hearing changes that may not be obvious in ordinary conversation. The results can guide decisions about hearing aids, further investigation, and strategies for protecting remaining hearing.

For people with hearing loss, hearing aids may make tinnitus less noticeable by improving access to external sounds. They can also improve communication, which may reduce listening effort and some of the stress associated with trying to follow conversations. Some devices include sound-enrichment features, although the appropriate choice depends on individual hearing needs and preferences.

Hearing aids are not a universal treatment for tinnitus, and their effects vary. However, when hearing loss is present, a hearing aid evaluation is often a more evidence-based next step than purchasing a supplement intended to increase inner ear circulation or repair hearing cells.

Cognitive Behavioural Therapy (CBT)

Cognitive behavioural therapy, or CBT, is one of the best-supported approaches for persistent, bothersome tinnitus. It does not attempt to convince people that the sound is imaginary or that they should simply ignore it. Instead, it helps them change the patterns of attention, worry, and distress that can make tinnitus dominate their everyday lives.

For example, someone who becomes anxious every time they notice the ringing may begin constantly checking whether it has become louder. That monitoring can make the sound more prominent and increase stress, which may in turn make the tinnitus harder to tolerate. CBT can help interrupt this cycle and develop more useful ways of responding to the sensation.

Clinical evidence indicates that CBT can reduce the negative impact of tinnitus and improve quality of life, even when the sound itself does not disappear. For someone experiencing significant distress, this can be a more reliable route to meaningful improvement than trying one supplement after another.

CBT does not imply that tinnitus is purely psychological. Tinnitus is a genuine sensory experience, and its effects can be influenced by biological, emotional, and behavioural processes at the same time. Treatment focuses on reducing the burden of the symptom rather than denying its existence.

Sound Enrichment and Managing Quiet Environments

Tinnitus is often more noticeable in quiet environments because there are fewer external sounds competing for attention. Introducing gentle background sound may help make the tinnitus less prominent, particularly at bedtime, during reading, or while working in a quiet room.

Options include quiet music, a fan, nature sounds, or a sound generator. The goal is not necessarily to drown out tinnitus completely or make the environment as loud as possible. A comfortable level of background sound may be enough to reduce the contrast between the tinnitus and the surrounding environment.

Sound enrichment does not work equally well for everyone, and the ideal approach varies. Some people prefer continuous low-level sound, while others benefit from using it only at specific times. People with significant sound sensitivity or a particular hearing disorder may need more individualized guidance.

Sleep, Stress, and Daily Habits

Poor sleep and stress can make tinnitus harder to manage, even when they are not the original cause. Fatigue may reduce concentration and make it more difficult to redirect attention away from the sound, while anxiety can cause someone to monitor their tinnitus more closely. This can create a frustrating cycle in which tinnitus disrupts sleep, and poor sleep makes tinnitus feel more intrusive the following day.

Maintaining a regular sleep schedule, allowing time to wind down before bed, engaging in enjoyable physical activity, and using appropriate relaxation techniques may help reduce some of this burden. These measures do not guarantee that tinnitus will become quieter, but they can support better functioning and resilience.

It is also worth identifying individual triggers without assuming that every proposed trigger applies to everyone. If caffeine, alcohol, or a particular activity consistently seems to aggravate symptoms, discussing that pattern with a healthcare professional may be useful. Broad and unnecessary restrictions are not automatically beneficial, and there is no single lifestyle rule that eliminates tinnitus for everyone.

When tinnitus is accompanied by persistent anxiety, depression, or severe sleep problems, treating those symptoms is an important part of care. The goal is to improve quality of life while ensuring that any underlying hearing, neurological, or other medical issues receive appropriate attention.

How to Choose Tinnitus Supplements More Carefully

If you are considering a supplement, begin by identifying what you are trying to improve. Are you dealing with a confirmed deficiency, a diagnosed migraine disorder, insomnia, or an underlying condition that has not yet been properly evaluated? Or are you looking for something that claims to eliminate tinnitus regardless of its cause? These are very different situations, and they call for different expectations.

Be particularly cautious of products that claim to repair damaged auditory nerves, regenerate inner ear hair cells, restore circulation to the cochlea, detoxify the auditory system, or permanently silence ringing. These claims require strong clinical evidence. Laboratory findings, animal experiments, theoretical mechanisms, and testimonials do not demonstrate that an oral supplement can achieve these results in people.

It is also important to distinguish between research on an isolated ingredient and research on the actual product being sold. Studies may use a specific extract, a defined amount of an ingredient, or a formulation that differs considerably from the supplement on the shelf. If the commercial product contains different amounts, different extracts, or a large proprietary blend, its effectiveness cannot simply be inferred from a study involving another formulation.

More ingredients do not necessarily mean more benefit. Combining numerous vitamins, minerals, herbal extracts, and antioxidants may increase the potential for adverse effects or interactions without providing evidence of additional effectiveness. Some ingredients may be underdosed, while others may duplicate nutrients already obtained from food or another supplement.

Safety deserves just as much attention as effectiveness. Ginkgo may increase bleeding risk in certain circumstances, high zinc intake can cause copper deficiency, magnesium supplements may be inappropriate for some people with impaired kidney function, and melatonin may cause unwanted sedation or interact with medication. Herbal ingredients can also vary in composition and quality, and products sold online do not always match the formulations used in clinical research.

When a deficiency or another relevant medical condition is identified, a targeted intervention with a clear indication is generally more rational than taking a broad tinnitus formula. A healthcare professional or pharmacist can help determine whether a supplement is appropriate, whether testing is needed, and whether it could interact with an existing medication.

Dr. Brian’s Summary

When you take a step back, one thing becomes clear: tinnitus is not a one-size-fits-all condition. It is a symptom with several possible causes, and there is no single supplement that has been proven to work reliably for everyone who experiences it.

Some cases improve when an underlying problem is treated. Earwax obstruction, certain middle ear conditions, medication-related effects, and some nutritional deficiencies may be manageable once they are correctly identified. In other cases, tinnitus may persist despite addressing the original cause, particularly when it is associated with longstanding hearing loss or changes in the way the auditory system processes sound.

Among the supplements discussed here, melatonin may be relevant for sleep difficulties associated with tinnitus, but its ability to treat the tinnitus itself remains uncertain. CoQ10 has produced promising preliminary findings in a small clinical trial involving age-related hearing loss, while Panax ginseng has shown limited signals in a small pilot study. Pycnogenol has also been studied in selected patients with Ménière’s disease, although the evidence is not strong enough to establish effectiveness. Magnesium may be relevant to conditions such as migraine or a nutritional deficiency, but it has not been established as a general tinnitus treatment.

NAC is another example of why the details matter. Research has investigated its potential to reduce noise-related hearing damage, but this does not establish that it can reverse existing cochlear injury or eliminate persistent tinnitus. Similarly, vitamin B12, vitamin D, zinc, and iron are most relevant when there is a genuine deficiency or another appropriate medical indication, not simply because someone experiences ringing in the ears.

Some of the most widely promoted tinnitus supplements, particularly ginkgo biloba and zinc in people without a relevant deficiency, have not shown convincing, consistent benefits in clinical trials. A product’s popularity, ingredient count, or proposed mechanism should not be mistaken for proof of effectiveness.

For persistent, bothersome tinnitus, current clinical guidance places greater emphasis on proper assessment, hearing care when appropriate, cognitive behavioural therapy, sound enrichment, and management of associated difficulties such as sleep disruption. These strategies are not guaranteed to eliminate tinnitus, but they have a stronger clinical foundation than relying on supplements alone.

If you are considering tinnitus supplements, the best first step is to identify the likely cause, check whether there is a treatable underlying problem, and establish realistic goals. A supplement that corrects a genuine deficiency may be worthwhile, and an intervention that improves sleep may make tinnitus easier to live with. However, neither should be assumed to repair the auditory system or permanently remove the sound.

Above all, do not let supplement experiments delay an assessment for sudden hearing loss, persistent one-sided tinnitus, heartbeat-synchronous sounds, or other concerning symptoms. Understanding the condition, seeking appropriate care, and choosing interventions based on the quality of the evidence offer a more sensible path toward relief than chasing a supposed miracle supplement.

Top supplement choices

Alpha Lipoic Acid (generic) – 1 to 3 caps / day
Alpha Lipoic Acid (Nervive) – 1 cap / day
CoQ10 – 1 to 2 caps / day
CoQ10 (ubiquinol) – 1 to 2 caps / day
Magnesium Aspartate – 1 cap / day
Magnesium Citrate – 1 to 4 caps / day
Magnesium Glycinate – 1 to 4 caps / day
Magnesium Malate – 2 to 6 caps / day
Magnesium Threonate – 3 to 6 caps / day
Melatonin (5 mg) – 1 cap before bed
N-acetyl cysteine – 2 to 3 caps / day
Panax ginseng – 2 to 6 caps / day
Pycnogenol – 1 to 3 caps / day
Vitamin B complex – 1 to 2 caps / day
Vitamin D (caps) – 1 to 2 caps / day
Vitamin D (drops) – 1 to 2 drops / day
Vitamin E – 1 cap / day

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Citations

Abadi RNS, Jazinaki MS, Bahari H, Rashidmayvan M, Amini MR, Aliakbarian M, Khodashahi R, Malekahmadi M. Impact of Melatonin Supplementation on Glycemic Parameters in Patients with Type 2 Diabetes: A Systematic Review and Meta-analysis. Curr Pharm Des. 2025;31(8):645-657. doi: 10.2174/0113816128345623241004080849. PMID: 39428939.

Abbasi R, Emami F, Atighechi S, Sadeghi Z. The Effect of Coenzyme Q10 on Tinnitus Severity and Sleep Quality in Patients with Presbycusis. Iran J Otorhinolaryngol. 2025;37(1):33-39. doi: 10.22038/ijorl.2024.79602.3681. PMID: 39850225; PMCID: PMC11750638.

Alkhatatbeh MJ, Hmoud ZL, Abdul-Razzak KK, Alem EM. Self-reported sleep bruxism is associated with vitamin D deficiency and low dietary calcium intake: a case-control study. BMC Oral Health. 2021 Jan 7;21(1):21. doi: 10.1186/s12903-020-01349-3. PMID: 33413308; PMCID: PMC7792220.

Attias J, Weisz G, Almog S, Shahar A, Wiener M, Joachims Z, Netzer A, Ising H, Rebentisch E, Guenther T. Oral magnesium intake reduces permanent hearing loss induced by noise exposure. Am J Otolaryngol. 1994 Jan-Feb;15(1):26-32. doi: 10.1016/0196-0709(94)90036-1. PMID: 8135325.

Cevette MJ, Barrs DM, Patel A, Conroy KP, Sydlowski S, Noble BN, Nelson GA, Stepanek J. Phase 2 study examining magnesium-dependent tinnitus. Int Tinnitus J. 2011;16(2):168-73. PMID: 22249877.

Chang PH, Liu CW, Hung SH, Kang YN. Effect of N-acetyl-cysteine in prevention of noise-induced hearing loss: a systematic review and meta-analysis of randomized controlled trials. Arch Med Sci. 2021 Mar 21;18(6):1535-1541. doi: 10.5114/aoms/109126. PMID: 36457967; PMCID: PMC9710288.

Dadgarnia M, Mandegari M, Zand V, Vaziribozorg S, Zare-Zardini H, Mousaviyazdi K, Kheradmandi M. The effect of vitamin B12 on idiopathic tinnitus. Am J Otolaryngol. 2024 Jan-Feb;45(1):104028. doi: 10.1016/j.amjoto.2023.104028. Epub 2023 Aug 22. PMID: 37647778.

Feldman L, Efrati S, Eviatar E, Abramsohn R, Yarovoy I, Gersch E, Averbukh Z, Weissgarten J. Gentamicin-induced ototoxicity in hemodialysis patients is ameliorated by N-acetylcysteine. Kidney Int. 2007 Aug;72(3):359-63. doi: 10.1038/sj.ki.5002295. Epub 2007 Apr 25. PMID: 17457375.

Hu C, Fan Y, Wu S, Zou Y, Qu X. Vitamin D supplementation for the treatment of migraine: A meta-analysis of randomized controlled studies. Am J Emerg Med. 2021 Dec;50:784-788. doi: 10.1016/j.ajem.2021.07.062. Epub 2021 Aug 11. PMID: 34879503.

Hurtuk A, Dome C, Holloman CH, Wolfe K, Welling DB, Dodson EE, Jacob A. Melatonin: can it stop the ringing? Ann Otol Rhinol Laryngol. 2011 Jul;120(7):433-40. doi: 10.1177/000348941112000703. PMID: 21859051.

Kim TS, Lee HS, Chung JW. The Effect of Korean Red Ginseng on Symptoms and Quality of Life in Chronic Tinnitus: A Randomized, Open-Label Pilot Study. J Audiol Otol. 2015 Sep;19(2):85-90. doi: 10.7874/jao.2015.19.2.85. Epub 2015 Sep 16. PMID: 26413574; PMCID: PMC4582451.

Korshnyak VО, Pulyk ОR, Stoyanov ОM. REHABILITATION OF PATIENTS WITH LONG-TERM AFTEREFFECTS OF MILD COMBAT TRAUMATIC BRAIN INJURY. Wiad Lek. 2022;75(1 pt 2):300-303. PMID: 35182139.

Luzzi R, Belcaro G, Hu S, Dugall M, Hosoi M, Cacchio M, Ippolito E, Corsi M. Improvement in symptoms and cochlear flow with pycnogenol in patients with Meniere’s disease and tinnitus. Minerva Med. 2014 Jun;105(3):245-54. PMID: 24988090.

Nocini R, Henry BM, Mattiuzzi C, Lippi G. Serum Vitamin D Concentration Is Lower in Patients with Tinnitus: A Meta-Analysis of Observational Studies. Diagnostics (Basel). 2023 Mar 8;13(6):1037. doi: 10.3390/diagnostics13061037. PMID: 36980345; PMCID: PMC10047354.

Park SH, Chung S, Chung MY, Choi HK, Hwang JT, Park JH. Effects of Panax ginseng on hyperglycemia, hypertension, and hyperlipidemia: A systematic review and meta-analysis. J Ginseng Res. 2022 Mar;46(2):188-205. doi: 10.1016/j.jgr.2021.10.002. Epub 2021 Oct 13. PMID: 35509826; PMCID: PMC9058846.

Person OC, Puga ME, da Silva EM, Torloni MR. Zinc supplementation for tinnitus. Cochrane Database Syst Rev. 2016 Nov 23;11(11):CD009832. doi: 10.1002/14651858.CD009832.pub2. PMID: 27879981; PMCID: PMC6464312.

Puliappadamb HM, Maiti R, Mishra A, Jena M, Mishra BR. Efficacy and Safety of Melatonin as Prophylaxis for Migraine in Adults: A Meta-analysis. J Oral Facial Pain Headache. 2022 Summer;36(3-4):207–219. doi: 10.11607/ofph.3211. Epub 2022 Nov 28. PMID: 36445912; PMCID: PMC10586587.

Sacchetto L, Monzani D, Apa E, Lovato A, Caragli V, Gherpelli C, Palma S, Genovese E, Nocini R. The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus through the Tinnitus Handicap Inventory Scores. Audiol Res. 2023 Jul 7;13(4):484-494. doi: 10.3390/audiolres13040043. PMID: 37489379; PMCID: PMC10366923.

Scasso F, Sprio AE, Canobbio L, Scanarotti C, Manini G, Berta GN, Bassi AM. Dietary supplementation of coenzyme Q10 plus multivitamins to hamper the ROS mediated cisplatin ototoxicity in humans: A pilot study. Heliyon. 2017 Feb 20;3(2):e00251. doi: 10.1016/j.heliyon.2017.e00251. PMID: 28239674; PMCID: PMC5318271.

Sereda M, Xia J, Scutt P, Hilton MP, El Refaie A, Hoare DJ. Ginkgo biloba for tinnitus. Cochrane Database Syst Rev. 2022 Nov 16;11(11):CD013514. doi: 10.1002/14651858.CD013514.pub2. PMID: 36383762; PMCID: PMC9668350.

Singh C, Kawatra R, Gupta J, Awasthi V, Dungana H. Therapeutic role of Vitamin B12 in patients of chronic tinnitus: A pilot study. Noise Health. 2016 Mar-Apr;18(81):93-7. doi: 10.4103/1463-1741.178485. PMID: 26960786; PMCID: PMC4918681.

Vidor LP, Torres IL, Custódio de Souza IC, Fregni F, Caumo W. Analgesic and sedative effects of melatonin in temporomandibular disorders: a double-blind, randomized, parallel-group, placebo-controlled study. J Pain Symptom Manage. 2013 Sep;46(3):422-32. doi: 10.1016/j.jpainsymman.2012.08.019. Epub 2012 Nov 27. PMID: 23195393.

Villani V, Zucchella C, Cristalli G, Galiè E, Bianco F, Giannarelli D, Carpano S, Spriano G, Pace A. Vitamin E neuroprotection against cisplatin ototoxicity: Preliminary results from a randomized, placebo-controlled trial. Head Neck. 2016 Apr;38 Suppl 1:E2118-21. doi: 10.1002/hed.24396. Epub 2016 Feb 5. PMID: 26849799.

von Luckner A, Riederer F. Magnesium in Migraine Prophylaxis-Is There an Evidence-Based Rationale? A Systematic Review. Headache. 2018 Feb;58(2):199-209. doi: 10.1111/head.13217. Epub 2017 Nov 13. PMID: 29131326.

Zibadi S, Rohdewald PJ, Park D, Watson RR. Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation. Nutr Res. 2008 May;28(5):315-20. doi: 10.1016/j.nutres.2008.03.003. PMID: 19083426.