Rhodiola vs Ashwagandha

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Rhodiola is a plant that grows in cold, high-altitude regions of Europe and Asia, and it’s the root that’s traditionally used in herbal medicine. It’s commonly described as an “adaptogen,” meaning it may help the body better cope with stress. You’ll often see rhodiola supplements marketed for reducing fatigue while boosting energy, stamina, strength, and mental performance. But when you take a closer look, the real question is how well it actually works—and how it compares to another popular adaptogen, ashwagandha.

Benefits of Rhodiola

Stress and Fatigue

When it comes to stress and fatigue, rhodiola gets a lot of attention. Some research suggests that taking around 200 mg twice daily for a few weeks may improve how stressed people feel and help them function better day to day. That said, many of these studies have limitations, such as lacking proper control groups, which makes the results less reliable. In people experiencing burnout, similar doses taken over longer periods—like 12 weeks—may slightly reduce stress and fatigue. However, because of weak study designs, it’s hard to draw strong conclusions.

Where rhodiola appears more promising is in reducing mental fatigue. Small studies show that it may help students feel less mentally drained during exams and allow shift workers to perform better on cognitive tasks after a couple of weeks of use. There’s also some evidence that higher doses can temporarily improve focus and memory, especially during sleep deprivation. Overall, rhodiola may help you feel more alert and less exhausted under stress, although it seems to influence perception more than physical stress markers like cortisol or blood pressure.

Exercise

When it comes to exercise performance, rhodiola produces mixed results. Some studies suggest it can make exercise feel easier and slightly lower heart rate during activity. However, these effects don’t appear to translate into meaningful improvements in strength, speed, or overall performance. In other words, it might help you feel less tired, but it likely won’t make you stronger or faster.

Mood Disorders

Rhodiola has also been studied for mood disorders, but the research here is still limited. Some small studies suggest it may help improve symptoms of mild to moderate depression after several weeks of use. In people with major depressive disorder, adding higher doses of rhodiola to standard treatment may provide additional benefits. There’s also early evidence that it could slightly reduce anxiety and stress in certain groups, such as students or individuals with generalized anxiety disorder. However, many of these studies are small or lack strong controls, so the overall quality of evidence remains low.

Rhodiola is often compared to ashwagandha, but the level of scientific evidence behind them isn’t equal. While there are no direct comparison studies, ashwagandha has been researched much more extensively, particularly for stress and anxiety. Multiple clinical trials show that doses between 300 and 600 mg can significantly reduce stress and anxiety levels. In some cases, ashwagandha even lowers cortisol, the body’s primary stress hormone—something rhodiola hasn’t consistently demonstrated.

In addition, ashwagandha may work even better when combined with lifestyle changes like improved diet or relaxation techniques, and it may enhance the effects of certain medications, such as SSRIs. There’s also evidence suggesting that taking it daily could help prevent stress-related weight gain. Because of this stronger and more consistent body of research, some clinical guidelines now include ashwagandha as a potential option for managing anxiety.

That said, rhodiola and ashwagandha don’t work in exactly the same way. Ashwagandha seems to have a clearer and more reliable effect on stress and anxiety, while rhodiola leans more toward improving fatigue, burnout, and mental performance. So, if your stress mainly shows up as exhaustion or brain fog, rhodiola may still be worth considering—just keep in mind that the evidence is less consistent.

Dr. Brian’s Verdict

Overall, rhodiola is an interesting supplement with potential benefits for stress-related fatigue and mental performance. However, based on the current research, it likely isn’t as effective or as well-supported as ashwagandha for managing stress and anxiety. If you’re deciding between the two, ashwagandha may be the more reliable choice, while rhodiola could still play a role if your main concern is fatigue or burnout.

Top supplement choices

Ashwagandha – 1 cap / day
Rhodiola – 1 cap / day
L-Theanine – 2 to 4 lozenge / day

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Citations

Akhgarjand C, Asoudeh F, Bagheri A, et al. Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2022;36(11):4115-4124. doi:10.1002/ptr.7598

Baker C, Kirby JB, O’Connor J, Lindsay KG, Hutchins A, Harris M. The Perceived Impact of Ashwagandha on Stress, Sleep Quality, Energy, and Mental Clarity for College Students: Qualitative Analysis of a Double-Blind Randomized Control Trial. J Med Food. 2022;25(12):1095-1101. doi:10.1089/jmf.2022.0042

Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med. 2008 Mar;14(2):175-80. doi: 10.1089/acm.2007.7117. PMID: 18307390.

Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012;34(3):255-262. doi:10.4103/0253-7176.106022

Choudhary D, Bhattacharyya S, Joshi K. Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial. J Evid Based Complementary Altern Med. 2017;22(1):96-106. doi:10.1177/2156587216641830

Cooley K, Szczurko O, Perri D, et al. Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974. PLoS One. 2009;4(8):e6628. Published 2009 Aug 31. doi:10.1371/journal.pone.0006628

Cropley M, Banks AP, Boyle J. The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms. Phytother Res. 2015 Dec;29(12):1934-9. doi: 10.1002/ptr.5486. Epub 2015 Oct 27. PMID: 26502953.

Darbinyan V, Aslanyan G, Amroyan E, Gabrielyan E, Malmström C, Panossian A. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nord J Psychiatry. 2007;61(5):343-8. doi: 10.1080/08039480701643290. Erratum in: Nord J Psychiatry. 2007;61(6):503. PMID: 17990195.

Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Rhodiola rosea in stress induced fatigue–a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. 2000 Oct;7(5):365-71. doi: 10.1016/S0944-7113(00)80055-0. PMID: 11081987.

Edwards D, Heufelder A, Zimmermann A. Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms–results of an open-label study. Phytother Res. 2012 Aug;26(8):1220-5. doi: 10.1002/ptr.3712. Epub 2012 Jan 6. PMID: 22228617.

Gao L, Wu C, Liao Y, Wang J. Antidepressants effects of Rhodiola capsule combined with sertraline for major depressive disorder: A randomized double-blind placebo-controlled clinical trial. J Affect Disord. 2020 Mar 15;265:99-103. doi: 10.1016/j.jad.2020.01.065. Epub 2020 Jan 15. PMID: 32090788.

Gopukumar K, Thanawala S, Somepalli V, Rao TSS, Thamatam VB, Chauhan S. Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Evid Based Complement Alternat Med. 2021 Nov 30;2021:8254344. doi: 10.1155/2021/8254344. PMID: 34858513; PMCID: PMC8632422.

Kasper S, Dienel A. Multicenter, open-label, exploratory clinical trial with Rhodiola rosea extract in patients suffering from burnout symptoms. Neuropsychiatr Dis Treat. 2017 Mar 22;13:889-898. doi: 10.2147/NDT.S120113. PMID: 28367055; PMCID: PMC5370380.

Majeed M, Nagabhushanam K, Murali A, Vishwanathan DT, Mamidala RV, Mundkur L. A Standardized Withania somnifera (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomized, Placebo-Controlled Study. J Integr Complement Med. 2024;30(5):459-468. doi:10.1089/jicm.2023.0279

Noreen EE, Buckley JG, Lewis SL, Brandauer J, Stuempfle KJ. The effects of an acute dose of Rhodiola rosea on endurance exercise performance. J Strength Cond Res. 2013 Mar;27(3):839-47. doi: 10.1519/JSC.0b013e31825d9799. PMID: 23443221.

Sarris J, Ravindran A, Yatham LN, et al. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce. World J Biol Psychiatry. 2022;23(6):424-455. doi:10.1080/15622975.2021.2013041

Shanely RA, Nieman DC, Zwetsloot KA, Knab AM, Imagita H, Luo B, Davis B, Zubeldia JM. Evaluation of Rhodiola rosea supplementation on skeletal muscle damage and inflammation in runners following a competitive marathon. Brain Behav Immun. 2014 Jul;39:204-10. doi: 10.1016/j.bbi.2013.09.005. Epub 2013 Sep 18. PMID: 24055627.

Shevtsov VA, Zholus BI, Shervarly VI, Vol’skij VB, Korovin YP, Khristich MP, Roslyakova NA, Wikman G. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine. 2003 Mar;10(2-3):95-105. doi: 10.1078/094471103321659780. PMID: 12725561.

Smith SJ, Lopresti AL, Fairchild TJ. Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial. J Psychopharmacol. 2023;37(11):1091-1104. doi:10.1177/02698811231200023

Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. 2000 Apr;7(2):85-9. doi: 10.1016/S0944-7113(00)80078-1. PMID: 10839209.