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Doctor Reviews: Alani Nu Fat Burner

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Alani Nu Fat Burner is not safe to use. Why? Because it contains an unusual extract called rauvolfia vomitoria.

This extract has been associated with problems in a clinical study, where 4 out of 10 patients taking Rauvolfia vomitoria dried root powder experienced neurological side effects like tremors and spasms. In two cases, the symptoms were severe enough to require treatment with antiparkinsonian medications.

What is Rauvolfia vomitoria?

Rauvolfia vomitoria, also referred to as poison devil’s-pepper, is a large shrub that grows in the lowland forests of Asia and West Africa.

Traditionally, it has been used to alleviate pain, treat snake bites, manage menstrual pain, and address infections.

Some speculate that Rauvolfia vomitoria extracts, which contain a chemical called rauwolscine, might help with fat loss because it’s similar in structure to another compound called yohimbine. There is a small amount of research that suggests yohimbine may help with fat loss, and exercise performance.

However, these findings are mostly from studies on mice, not humans. When it comes to research involving humans, yohimbine doesn’t actually seem to offer any benefits for weight loss or fat metabolism.

It also seems to lack any benefits for weight loss or athletic performance if you’re exercising.

But perhaps a bigger problem than it being ineffective for fat or weight loss, is that these extracts often contain small amounts of drugs called reserpine.

In the past, reserpine was used to treat high blood pressure, but it fell out of favor due to more effective and safer alternatives available.

Reserpine has been linked to significant cardiovascular and neurological side effects including slowed and irregular heartbeats, heart attacks, seizures, and depression.

Ingredients of Alani Nu Fat Burner

Now let’s talk about the rest of the supplement. Here are the doses per capsule. The recommended dosing is 1 per day.

Alani-Nu-Fat-Burner-review-ingredients
Ingredients of Alani Nu Fat Burner supplement.

We’re going to analyze each ingredient to see whether they contain a sufficient dose, whether it contains the active compounds to work, and how effective they might be for weight loss. Then at the very end, I’ll look into cheaper alternatives and give the supplement an overall rating.

Caffeine

First up, we have caffeine. Whether it’s from so-called “micronized” extracts or pure caffeine, they all work the same way. Caffeine can only aid in weight loss if it boosts your physical activity.

The Alani Nu Fat Burner provides around 100 mg of caffeine per day, which is roughly the same as a cup of coffee.

Out of all the components in this fat burner, caffeine is the one that comes closest to having an impact on fat burning and weight loss.

Griffonia seed extract

Next, we have Griffonia seed extract. This extract contains a chemical called 5-Hydroxytryptophan (5-HTP). People mostly take it to help with mood problems like depression.

Some studies have looked into whether it can also help with obesity. These studies are quite small and not very strong, but they suggest that 5-HTP might slightly help with reducing emotional eating and snacking.

Unfortunately, the evidence is too weak to prove that this will be enough to cause any actual weight loss.

It’s also worth noting that the studies used 750 to 900 mg of purified 5-HTP daily. Alani Nu Fat Burner contains only 50 mg of crude Griffonia seed extract. So, even if there are benefits, the fat burner does not contain enough to make a difference.

Dimethylethanolamine (DMAE)

Moving on to Dimethylethanolamine (DMAE), this ingredient was once promoted for children with ADHD due to its possible nootropic effects.

Nootropics are substances that might enhance brain performance and cognition. DMAE could potentially contribute to better cognition, but the dose in Alani Nu Fat Burner is way too low. Research usually involves doses of around 500 mg, much higher than what’s present here.

Grains of Paradise

Now, let’s talk about Grains of Paradise. This herb, related to ginger, is claimed by some to aid fat burning and weight loss. This idea primarily comes from a small study that seemed to show benefits in fat reduction.

The study looked into its effects on overall energy use and fat around organs. However, the study was conducted on only 19 people, hardly enough to draw good conclusions.

Nevertheless, in the study, those who took the Grains of Paradise extract had less fat around their organs compared to those who took a placebo.

However, there were no differences in subcutaneous fat, body fat percentage, or total weight loss. Interestingly, the placebo group seemed to lose more weight overall, although this finding isn’t very strong.

Furthermore, other research suggests that Grains of Paradise does not really make a substantial impact on your weight or fat loss.

Rauvolfia vomitoria extract

Finally, we have Rauvolfia vomitoria extract. As mentioned earlier, there’s no evidence supporting its ability to help with weight or fat loss.

Alani Nu Fat Burner Side effects and warnings

Not only is taking Rauvolfia vomitoria potentially unsafe and has been directly linked to serious neurological and cardiac problems in clinical trials, but it also lacks efficacy for fat burning.

Perhaps the intention was to appear unique or stand out as an interesting supplement, but regardless of the reason, it’s a terrible choice for a supplement branded as a fat burner

Additionally, rauwolscine has the potential to cause birth defects and is considered a possible teratogen. This makes it crucial to avoid its use during pregnancy.

Indeed, both rauwolscine and yohimbine are ingredients not permitted in Canada due to safety concerns. As a result, it’s likely that the Alani Nu Fat Burner cannot be legally purchased in Canada and Health Canada strongly advises discontinuing the use of these products and urges individuals to report any of these items being sold.

This isn’t the first instance where Alani Nu products have clashed with Health Canada’s regulations. The Canadian Food Inspection Agency (CFIA) is also cautioning people against consuming the Alani Nu energy drink.

Health Canada has established a maximum caffeine limit of 180 milligrams for energy drinks. However, the Alani Nu energy drink contains 200 milligrams.

As a result, the CFIA has issued this warning to avoid it, and taken action to remove Alani Nu energy drinks from store shelves.

Is Alani Nu Fat Burner effective?

Overall, Alani Nu Fat Burner is going to be no more effective than drinking a cup of coffee.

Alani-Nu-Fat-Burner-review-ingredient-analysis
Alani Nu Fat Burner supplement ingredient analysis.

In fact, it might not even be as good as a cup of coffee, since coffee contains other beneficial compounds like chlorogenic acid—a compound that actually has some evidence supporting its use in fat metabolism.

In contrast, Alani Nu Fat Burner contains Rauvolfia vomitoria—a compound that lacks any evidence it can help with fat or weight loss and has the potential to cause neurological and possibly serious side effects.

Overall review: Alani Nu Fat Burner

Alani-Nu-Fat-Burner-review-overall-summary-rating
Overall Alani Nu Fat Burner review rating.

Reviewing Alani Nu Fat Burner by effectiveness for weight loss, I’m giving it an D. It’s no better than a weak caffeine supplement, and will likely be outdone by a single cup of coffee when it comes to fat metabolism.

Reviewing Alani Nu Fat Burner by cost, I’m giving it a D. You can replicate what Alani Nu Fat Burner is trying to provide you with better quality generics for many times less.

Reviewing Alani Nu Fat Burner for safety, I’m giving it a D. It contains Rauvolfia vomitoria which is unsafe to use.

Overall review, I’m giving Alani Nu Fat Burner an F. I would recommend you stay away from it.

Top alternatives to Alani Nu Fat Burner

If you’re looking to achieve similar effects, but better than those of Alani Nu Fat Burner, I would combine a quality

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Citations

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Callahan MF, Beales M, Oltmans GA. Yohimbine and rauwolscine reduce food intake of genetically obese (obob) and lean mice. Pharmacol Biochem Behav. 1984;20(4):591-599. doi:10.1016/0091-3057(84)90309-5

Cangiano C, Ceci F, Cascino A, et al. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. Am J Clin Nutr. 1992;56(5):863-867. doi:10.1093/ajcn/56.5.863

Ceci F, Cangiano C, Cairella M, et al. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects. J Neural Transm. 1989;76(2):109-117. doi:10.1007/BF01578751

Coleman N, Dexheimer P, DiMascio A, Redman W, Finnerty R. Deanol in the treatment of hyperkinetic children. Psychosomatics. 1976;17(2):68-72. doi:10.1016/S0033-3182(76)71146-0

Eluwa MA, Udoaffah MT, Vulley MB, et al. Comparative study of teratogenic potentials of crude ethanolic root bark and leaf extract of Rauwolfia vomitoria (apocynaceae) on the fetal heart. N Am J Med Sci. 2010;2(12):592-595. doi:10.4297/najms.2010.2592

Harpaz E, Tamir S, Weinstein A, Weinstein Y. The effect of caffeine on energy balance. J Basic Clin Physiol Pharmacol. 2017;28(1):1-10. doi:10.1515/jbcpp-2016-0090

Lee A, Lim W, Kim S, Khil H, Cheon E, An S, Hong S, Lee DH, Kang SS, Oh H, Keum N, Hsieh CC. Coffee Intake and Obesity: A Meta-Analysis. Nutrients. 2019 Jun 5;11(6):1274. doi: 10.3390/nu11061274. PMID: 31195610; PMCID: PMC6628169.

Lewis JA, Young R. Deanol and methylphenidate in minimal brain dysfunction. Clin Pharmacol Ther. 1975;17(5):534-540. doi:10.1002/cpt1975175534

Lobay D. Rauwolfia in the Treatment of Hypertension. Integr Med (Encinitas). 2015 Jun;14(3):40-6. PMID: 26770146; PMCID: PMC4566472.

Obembe A, Sokomba EN, Sijuwola OA, et al. Antipsychotic effects and tolerance of crude Rauvolfia vomitoria in Nigerian psychiatric inpatients. Phytotherapy Research. 1994;8(4):218-23.

Ostojic SM. Yohimbine: the effects on body composition and exercise performance in soccer players. Res Sports Med. 2006;14(4):289-299. doi:10.1080/15438620600987106

Ruiz-Moreno C, Amaro-Gahete FJ, González-García J, et al. Caffeine increases exercise intensity and energy expenditure but does not modify substrate oxidation during 1 h of self-paced cycling. Eur J Nutr. 2022;61(6):3285-3292. doi:10.1007/s00394-022-02894-z

Sugita J, Yoneshiro T, Hatano T, et al. Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men. Br J Nutr. 2013;110(4):733-738. doi:10.1017/S0007114512005715

Sugita J, Yoneshiro T, Sugishima Y, et al. Daily ingestion of grains of paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans. J Nutr Sci Vitaminol (Tokyo). 2014;60(1):22-27. doi:10.3177/jnsv.60.22

Tabrizi R, Saneei P, Lankarani KB, et al. The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2019;59(16):2688-2696. doi:10.1080/10408398.2018.1507996

Attributions

By Ji-Elle – Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=69412341


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